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Names | |
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IUPAC name
2′,4′,5′-Trimethoxy-6′′,6′′-dimethyl-6′′H-pyrano[2′′,3′′:7,8]isoflavone
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Systematic IUPAC name
8,8-Dimethyl-3-(2,4,5-trimethoxyphenyl)-4H,8H-benzo[1,2-b:3,4-b′]dipyran-4-one | |
Other names
Barubigeron
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Identifiers | |
3D model (JSmol)
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ChemSpider | |
MeSH | C543999 |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C23H22O6 | |
Molar mass | 394 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Barbigerone is one of a few pyranoisoflavones among several groups of isoflavones. It was first isolated from the seed of a leguminous plant Tephrosia barbigera; hence the name "barbigerone".[1] Members of the genus Millettia are now known to be rich in barbigerone, including M. dielsiena,[2] M. ferruginea,[3] M. usaramensis,[4] and M. pachycarpa.[5] It has also been isolated from the medicinal plant Sarcolobus globosus.[6] Barbigerone from S. globosus is validated to have significant antioxidant property.[7] Barbigerone exhibits profound antiplasmodial activity against the malarial parasite Plasmodium falciparum.[8] It is also demonstrated that it has anti-cancer potential as it causes apoptosis of murine lung-cancer cells.[9]