Chuzhou or Chu Prefecture (楚州) was a zhou (prefecture) in imperial China seated in modern Huai'an, Jiangsu, China. It existed (intermittently) from 581 to 1228.

The administrative region of Chuzhou in the Tang dynasty is in modern Jiangsu. It probably includes parts of modern:

• Under the administration of Huai'an:
  • Huai'an
  • Xuyi County
  • Jinhu County
  • Hongze County
• Under the administration of Yangzhou:
  • Baoying County
• Under the administration of Yancheng:
  • Jianhu County

• Shi Weile, ed. (2005). Zhongguo Lishi Diming Da Cidian (中国历史地名大词典) [Large Dictionary of Chinese Historical Place Names] (in Chinese). China Social Sciences Press. pp. 2675–2676. ISBN 7-5004-4929-1.