An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors.
Three main kinds of ERAs exist:
Macitentan, ambrisentan and bosentan are mainly used for the treatment of pulmonary arterial hypertension, while atrasentan is an experimental anti-cancer drug.
Prostacyclin analogues | |
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Endothelin receptor antagonists | |
PDE5 inhibitors | |
sGC stimulators | |
Adjunctive therapy |
Sympatholytics (antagonize α-adrenergic vasoconstriction) | |||||
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Other antagonists |
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