Protein-coding gene in the species Homo sapiens
Formin-binding protein 1-like is a protein that in humans is encoded by the FNBP1L gene.[5][6]
Function
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.[6]
Clinical significance
FNBP1L polymorphisms, specifically the SNP rs236330 has been associated with normally varying intelligence differences in adults[7] and in children.[8]