George H. Sanford (December 14, 1836 – November 25, 1871) was an American politician from New York.
Sanford was born in Queensbury, New York, to Assemblyman George Sanford and Louisa (Gibbs) Sanford. At age twelve, he became a clerk in a store in Glens Falls while attending the common schools in winter. Two years later he became a shipping clerk in a wholesale lumber business in Albany, working there for six years during the navigation season. In winter, he attended school, or went lumbering in Genesee County, New York, and Potter County, Pennsylvania; and attended for one year Rensselaer Polytechnic Institute. About 1857, he removed to Syracuse, and became a merchant, engaging in the lumber and salt trade. In January 1861, he married Helen Breese Stevens (born 1839). In the spring of 1862, he removed to Oneida, in Madison County. He was Vice President of the Oneida Savings Bank; and a director of the Oneida Valley National bank, and the Rome and Clinton Railroad.
He was a delegate to the 1864 Democratic National Convention; Supervisor of the Town of Verona in 1865 and 1866; a member of the New York State Assembly (Oneida County, 3rd D.) in 1867; a delegate to the 1868 Democratic National Convention; and a member of the New York State Senate (19th D.) in 1870 and 1871.
He was buried at the Glenwood Cemetery in Oneida.