His most important work is A Critical Survey of the History of the Armenian People (vols. 1–3, 1945–57). He was awarded the Order of the Red Banner of Labour.[2]
Manandian was born in Akhaltsikhe. From 1880 to 1883 he received his primary education at the Karapetyan College in his hometown. From 1883 to 1893 he studied at the First Gymnasium in Tiflis, and from 1893 to 1897 attended universities in Jena, Leipzig and Strasbourg, completing his PhD degree. In 1898 he graduated from the Faculty of Oriental Languages of the University of St. Petersburg, and in 1909 from the Faculty of Law of the University of Dorpat (now Tartu). From 1900 to 1905 Manandian taught at the Gevorgian Seminary of Ejmiatsin, from 1905 to 1907 at the First and Second Men's Gymnasiums in Tiflis, from 1906 to 1907 at the Nersisian School, from 1911 to 1913 at the People's University of Baku, and from 1915 to 1919 at a mercantile school.
In December 1919 Manandian was invited to Yerevan State University (YSU) and appointed acting dean of the Faculty of History and Linguistics. From 1921 to 1922 he was rector at YSU. From 1922 to 1923 he was the dean of the faculties of Art and Historiography, from 1921 to 1925 the head of the chair of the History of the Armenian People and professor of the same chair.
In 1925 Manandian was awarded the title of professor. In 1938, he attained his title of Doctor of Historical Sciences.
In 1925 he was elected a member of the Institute of Sciences and Arts of Armenia, in 1939 he became a member of the Academy of Sciences of the Soviet Union, and in 1943 his candidacy was approved as a founding member of the Academy of Sciences of the Soviet Union. He was the first to teach ancient and medieval history of the Armenian people at YSU. In 1931 he interrupted his pedagogical activities and engaged in scientific work. He died on February 4, 1952, in Yerevan. His ashes are interred at the Pantheon at Komitas Park.
A monument is erected in front of building No. 62 on Teryan Street in Yerevan. His bronze bust is placed in the lobby of the YSU main building. A street is named after him in the Shengavit District of Yerevan.
Manandyan, Hakob (1928). Materials About the Economic History of Ancient Armenia: Vol. II (in Armenian). Yerevan.((cite book)): CS1 maint: location missing publisher (link)
Manandyan, Hakob (1929). "H. H. Manandyan's Speech at the Askanaz Mravyan Funeral". Khorhrdayin Hayastan (in Armenian) (245). Yerevan: 1.
Manandyan, Hakob (1930). About Trade and the Cities of Armenia in Connection with the Global Trade of Ancient Times (in Russian) (1st ed.). Yerevan: PetHrat.
Manandyan, Hakob (1931). "Old Roads of Armenia According to Tabula Peutingeriana". Teghekagir (in Armenian) (5). Yerevan: Arm. SSR Institute of Arts and Science: 65–89.
Manandyan, Hakob (1931). Old Roads of Armenia According to Tabula Peutingeriana (in Armenian) (1st ed.). Yerevan.((cite book)): CS1 maint: location missing publisher (link)
Manandyan, Hakob (1932). Small Studies(PDF) (in Armenian and German). Yerevan: Melkonyan Fund. Retrieved 18 July 2017.
Manandyan, Hakob (1935). "Medieval Itinerarium in the 10th Century Armenian Manuscripts". Academy of Sciences of the USSR (in Russian). XLV. Moscow-Leningrad: 723–728.
Manandyan, Hakob (1937). "Speech at the Extraordinary Congress of the Armenian SSR Council". Khorhrdayin Hayastan (in Armenian) (67). Yerevan: 2.
Manandyan, Hakob (1938). "The Grand Celebration (to Celebrate the 1000th Anniversary of Armenian Folk Epic Poem "Daredevils of Sassoun")". Kommunist (in Russian) (229): 3.
Theon (1938). Hakob Manandyan (ed.). On Rhetoric (in Armenian, Ancient Greek, German, and Russian). Yerevan: Arm. SSR Institute of Arts and Science.
Manandyan, Hakob (1939). The Popular Rebellions in Armenia Against the Arabic Dominion (in Armenian). Yerevan: Arm. SSR State University Publishing House.
Manandyan, Hakob (1939). "H. H. Manandyan's Speech at the Jubilee Session to Celebrate the 1000th Anniversary of Armenian Folk Epic Poem "Daredevils of Sassoun"". Khorhrdayin Hayastan (in Armenian) (213). Yerevan: 3.
Manandyan, Hakob (1939). "Revived Armenia". Sovietskaya Nauka (in Russian) (12). Moscow: 141–145.
Manandyan, Hakob (1939). The Popular Rebellions in Armenia Against the Arabic Dominion (in Russian). Yerevan: Arm. SSR State University Publishing House.
Manandyan, Hakob (1939). "Raising the Young Cadres". Izvestia (in Russian) (24): 3.
Manandyan, Hakob (1939). "The Speech of the Academic H. H. Manandyan (at the Meeting of the Academic Council of Arm. BAS on the Occasion of His Election to the Full Membership of the AS of the USSR)". Kommunist (in Russian) (30): 3.
Manandyan, Hakob (1940). "The Speech of the Academic H. H. Manandyan at the Jubilee Scientific Session of the Armenian Branch of the Academy of Sciences of the USSR". Sovetakan Hayastan (in Armenian) (270): 1.
Manandyan, Hakob (1940). "Academic I. A. Javakhishvili. An Obituary". Sovetakan Hayastan (in Armenian) (271): 1.
Manandyan, Hakob (1940). "The Speech of the Deputy H. H. Manandyan at the First Session of the City Council of the Deputies of the Workers of Yerevan". Khorhrdayin Hayastan (in Armenian) (2): 1.
Manandyan, Hakob (1940). Cities of Armenia in the 10-11 Centuries (in Armenian). Yerevan: Armenian Branch of the Academy of Sciences of the USSR.
Manandyan, Hakob (1940). "A Preface to the Study "Tigranes II and Rome"". Kommunist (in Russian) (36). Yerevan: 3.
Manandyan, Hakob (1940). "The Speech of the Deputy H. H. Manandyan at the First Session of the City Council of the Deputies of the Workers of Yerevan". Kommunist (in Russian) (2). Yerevan: 1.
Manandyan, Hakob (1941). "Shoulder to Shoulder with All the Nation". Sovetakan Hayastan (in Armenian) (148). Yerevan: 1.
Manandyan, Hakob (1941). "To All the Armenians of Foreign Countries". Sovetakan Hayastan (in Armenian) (195). Yerevan: 1.
Manandyan, Hakob (1941). "To All the Armenians of Foreign Countries". Sovetakan Grakanutyun (in Armenian) (8). Yerevan: 3–4.
Manandyan, Hakob (1941). "To All the Armenians of Foreign Countries". Izvestia Arm. FANa SSSR (in Russian) (7). Yerevan: 3–6.
Manandyan, Hakob (1941). "To All the Armenians of Foreign Countries". Kommunist (in Russian) (194). Yerevan: 1.
Manandyan, Hakob (1941). "To All the Armenians of Foreign Countries". Pravda (in Russian) (227). Moscow: 3.
Manandyan, Hakob (1942). "The Voice of the History"(PDF). Banvoragyughatsiakan Karmir Banaki Martik (in Armenian) (9). Tbilisi: 2. Retrieved 18 July 2017.