The Institute for the Encouragement of Scientific Research and Innovation of Brussels or ISRIB (French: Institut d'Encouragement de la Recherche Scientifique et de l'Innovation de Bruxelles – IRSIB, Dutch: Instituut ter bevordering van het Wetenschappelijk Onderzoek en de Innovatie van Brussel – IWOIB) promotes scientific research and technological innovation in the Brussels-Capital Region of Belgium within companies, universities and higher education institutes within the region. It provides support to both profit-oriented research and non-profit-oriented-research.
The ISRIB was founded by the Brussels decree of 26 June 2003, and it started its activities on 1 July 2004.