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Layasika Lagoon Natural Reserve is a nature reserve in Nicaragua. It is one of the 78 reserves that are under official protection in the country.

v t e Protected areas of Nicaragua
Nature Reserves	Nicaragua portal Alamikamaba Apoyo Lagoon Asososca Lagoon Bismuna Raya Lagoon Cabo Viejo-Tala-Sulamas Cerro Apante Cerro Arenal Cerro Banacruz Cerro Cola Blanca Cerro Cumaica–Cerro Alegre Cerro Guabule Cerro Kilambé Cerro Mombachito-La Vieja Cerro Musún Cerro Pancasan Cerro Quiabuc-Las Brisas Cerro Silva Cerro Tisey–Estanzuela Cerro Wawashang Chiltepe Peninsula Chocoyero-El Brujo Cordillera de Yolaina Cordillera Dipilto and Jalapa Cosigüina Volcano El Arenal Estero Padre Ramos Estero Real Fila Masigüe Juan Venado Island Kligna Kukalaya Lagoon La Máquina Layasika Lagoon Limbaika Llanos de Karawala Llanos de Makantaka Macizos de Peñas Blancas Maderas Volcano Makantaka Mesas de Moropotente Mecatepe Lagoon Miraflor Mombacho Volcano Nejapa Lagoon Pahara Lagoon Punta Gorda Río Manares Salto Río Yasika Sierra Amerrisque Sierra Quirragua Tepesomoto-Pataste Tiscapa Lagoon Tisma Lagoon Volcán Maderas Volcán Telica Rota Volcán Pilas El Hoyo Volcán San Cristóbal Volcán San Cristóbal-Casita Volcán Yali Yolaina Yulu Yulu Karata
Genetic / Biosphere / Biological / Forest Reserves	Apacunca Genetic Reserve Bosawás Biosphere Reserve Cayos Miskitos Biological Reserve Indio Maíz Biological Reserve Llanos de Apacunca Genetic Reserve Selva Negra Cloud Forest Reserve Yucul Genetic Reserve
Wildlife Refuges	Chacocente Los Guatuzos Río San Juan
National Monuments / Parks / etc	Hurricane Mitch Victims National Monument La Inmaculada Fort Historical Site Masaya Volcano National Park Solentiname National Monument Somoto Canyon National Monument Zapatera Archipelago National Park

13°38′20″N 83°42′14″W / 13.639°N 83.704°W / 13.639; -83.704