The following is a list of academic buildings in the Pennsylvania State University system:

University Park

Ag Hill area

• Agricultural Engineering Building
• Agricultural Sciences and Industries Building
• Berkey Creamery
• Business Building
• Food Science Building
• Forest Resources Building
• Headhouse Buildings I-III
• Henning Building
• Lewis Katz Building
• McCoy Natatorium
• Tyson Building

Allen Road area

• Arts Building
• CEDAR Building
• Chambers Building
• Ford Building
• Moore Building
• Music Building I
• Music Building II
• Rackley Building

College of Science area

• Althouse Laboratory
• Boucke Building
• Buckhout Laboratory
• Chemical & Biomedical Engineering Building (CBEB)
• Chemistry Building
• Davey Laboratory
• Frear North Building
• Frear South Building
• Life Sciences Building
• Mueller Laboratory
• Osmond Laboratory
• Ritenour Building
• Thomas Building
• Wartik Laboratory
• Whitmore Laboratory

EMS and Engineering East area

• Deike Building
• Electrical Engineering East Building
• Electrical Engineering West Building
• Engineering Units A-C
• Hammond Building (Penn State)|Hammond Building
• Hosler Building
• Reber Building
• Sackett Building
• Steidle Building
• Willard Building

EMS and Engineering West area

• Applied Research Laboratory
• Applied Sciences Building
• Earth-Engineering Sciences Building
• Hallowell Building
• Leonhard Building
• Information Sciences and Technology Building
• Research West Building
• Walker Building

Hastings Road area

• Academic Activities Building
• Forest Resources Laboratory
• Pegula Ice Arena
• Materials Research Laboratory
• Research East Building

HUB-Robeson Center area

• Grange Building
• Health and Human Development East Building
• Henderson Building
• Henderson South Building
• McAllister Building
• White Building
• Biobehavioral Health Building

Innovation Park area

• Innovation Park
• Lubert Building

Intramural Building area

• Intramural Building
• Shields Building
• Wagner Building

Nittany Lion Inn area

• Biomechanics Laboratory
• Carpenter Building
• Keller Building
• Kern Building
• Mateer Building

Palmer Museum of Art area

• Armsby Building
• Arts Cottage
• Borland Building
• Ferguson Building
• Forum Building
• Patterson Building
• Pavilion Theatre
• Stuckeman Family Building
• Visual Arts Building
• Weaver Building

Pattee Library area

• Burrowes Building
• Carnegie Building
• Chandlee Laboratory
• Old Botany Building
• Oswald Tower
• Pond Laboratory
• Sparks Building

Rec Hall area

• Noll Laboratory
• Rec Hall

Commonwealth campuses

This portion of the list excludes those buildings in which an insignificant number of courses are held or those buildings that have an obvious use other than that of academics, such as libraries, administration buildings, and student centers.

Abington

• Sutherland Hall
• Lares Building
• Rydal Building
• Conference Center
• Spring House
• Woodland Building
• Athletic Building
• Cloverly Building

Altoona

• Cypress Building
• Force Advanced Technology Center
• Hawthorn Building
• Holtzinger Engineering Building
• Science Building
• Smith Building

Beaver

• General Classroom Building
• Laboratory Classroom Building
• Michael Baker Jr. Building

Berks

• Beaver Community Center
• Boscov-Lakin Information Commons
• Franco Building
• Luerssen Building
• Perkins Student Center
• Gaige Technology and Business Innovation Building

Brandywine

• Commons Building
• Main Building
• Orchard Hall
• Tomezsko Building
• Vairo Library

DuBois

• DEF Technology Center
• Multipurpose Building
• Smeal Building
• Swift Building

Erie

• Jack Burke Research & Economic Development Center
• Kochel Center
• Nick Building
• Otto Behrend Science Building

Fayette

• Biomedical Building
• Eberly Building
• Engineering Building
• Williams Building

Greater Allegheny

• Crawford Building
• Fitness and Cultural Center (FCC)
• Kelly Library
• Frable Building
• Main Building
• Ostermayer Laboratory

Great Valley

• Main building
• The Conference Center at Penn State Great Valley (formerly known as the Safeguard Scientifics Building prior to 2010)

Harrisburg

• Capital Union Building
• Educational Activities Building
• Engineering Technology Laboratory
• Library
• Olmsted Building
• Science and Technology Building
• Student Enrichment Center
• Swatara Building

Hazleton

• Butler Learning Center
• Graham Academic Building
• Kostos Building
• Memorial Building
• Physical Education Building

Lehigh Valley

• Academic Building
• Corporate Learning Center
• Modular Building

Mont Alto

• General Studies Building
• Science & Technology Center

New Kensington

• Activities Building
• Blissell Center
• Conference Center
• Engineering Building
• Science and Technology Building
• Science Building

Schuylkill

• Classroom Building
• Multipurpose Building

Shenango

• Forker Laboratory
• Lecture Hall
• Physical Therapy Building
• Science Building
• Sharon Hall

Wilkes-Barre

• Athletics & Recreation Building
• Nesbitt Academic Commons
• Science Building
• Technology Center

Worthington Scranton

• Business Building
• Dawson Building
• Gallagher Conference Center
• Student Learning Center

York

• Grumbacher IST Center
• Main Classroom Building
• Pullo Performing Arts Center