Protein-coding gene in the species Homo sapiens
Moesin is a protein that in humans is encoded by the MSN gene .[5] [6]
Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin . ERM proteins appear to function as cross-linkers between plasma membranes and actin -based cytoskeletons .[7]
Moesin is localized to filopodia and other membranous protrusions that are important for cell–cell recognition and signaling and for cell movement.[7]
Moesin has FERM domain at N-terminal .
Tsukita S, Yonemura S (1997). "ERM (ezrin/radixin/moesin) family: from cytoskeleton to signal transduction". Curr. Opin. Cell Biol . 9 (1): 70–5. doi :10.1016/S0955-0674(97)80154-8 . PMID 9013673 .
Vaheri A, Carpén O, Heiska L, Helander TS, Jääskeläinen J, Majander-Nordenswan P, Sainio M, Timonen T, Turunen O (1997). "The ezrin protein family: membrane-cytoskeleton interactions and disease associations". Curr. Opin. Cell Biol . 9 (5): 659–66. doi :10.1016/S0955-0674(97)80119-6 . PMID 9330869 .
Matarrese P, Malorni W (2005). "Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death" . Cell Death Differ . 12 (Suppl 1): 932–41. doi :10.1038/sj.cdd.4401582 . PMID 15818415 .
Gary R, Bretscher A (1995). "Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F-actin binding site" . Mol. Biol. Cell . 6 (8): 1061–75. doi :10.1091/mbc.6.8.1061 . PMC 301263 . PMID 7579708 .
Schwartz-Albiez R, Merling A, Spring H, Möller P, Koretz K (1995). "Differential expression of the microspike-associated protein moesin in human tissues". Eur. J. Cell Biol . 67 (3): 189–98. PMID 7588875 .
Schneider-Schaulies J, Dunster LM, Schwartz-Albiez R, Krohne G, ter Meulen V (1995). "Physical association of moesin and CD46 as a receptor complex for measles virus" . J. Virol . 69 (4): 2248–56. doi :10.1128/JVI.69.4.2248-2256.1995 . PMC 188894 . PMID 7884872 .
Wilgenbus KK, Hsieh CL, Lankes WT, Milatovich A, Francke U, Furthmayr H (1994). "Structure and localization on the X chromosome of the gene coding for the human filopodial protein moesin (MSN)" . Genomics . 19 (2): 326–33. doi :10.1006/geno.1994.1065 . PMID 8188263 .
Gary R, Bretscher A (1993). "Heterotypic and homotypic associations between ezrin and moesin, two putative membrane-cytoskeletal linking proteins" . Proc. Natl. Acad. Sci. U.S.A . 90 (22): 10846–50. Bibcode :1993PNAS...9010846G . doi :10.1073/pnas.90.22.10846 . PMC 47875 . PMID 8248180 .
Dunster LM, Schneider-Schaulies J, Löffler S, Lankes W, Schwartz-Albiez R, Lottspeich F, ter Meulen V (1994). "Moesin: a cell membrane protein linked with susceptibility to measles virus infection" . Virology . 198 (1): 265–74. doi :10.1006/viro.1994.1029 . PMID 8259662 .
Nakamura F, Amieva MR, Furthmayr H (1995). "Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets" . J. Biol. Chem . 270 (52): 31377–85. doi :10.1074/jbc.270.52.31377 . PMID 8537411 .
Ott DE, Coren LV, Kane BP, Busch LK, Johnson DG, Sowder RC, Chertova EN, Arthur LO, Henderson LE (1996). "Cytoskeletal proteins inside human immunodeficiency virus type 1 virions" . J. Virol . 70 (11): 7734–43. doi :10.1128/JVI.70.11.7734-7743.1996 . PMC 190843 . PMID 8892894 .
Hecker C, Weise C, Schneider-Schaulies J, Holmes HC, ter Meulen V (1997). "Specific binding of HIV-1 envelope protein gp120 to the structural membrane proteins ezrin and moesin" . Virus Res . 49 (2): 215–23. doi :10.1016/S0168-1702(97)00039-7 . PMC 7126478 . PMID 9213396 .
Serrador JM, Alonso-Lebrero JL, del Pozo MA, Furthmayr H, Schwartz-Albiez R, Calvo J, Lozano F, Sánchez-Madrid F (1997). "Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization" . J. Cell Biol . 138 (6): 1409–23. doi :10.1083/jcb.138.6.1409 . PMC 2132557 . PMID 9298994 .
Reczek D, Berryman M, Bretscher A (1997). "Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family" . J. Cell Biol . 139 (1): 169–79. doi :10.1083/jcb.139.1.169 . PMC 2139813 . PMID 9314537 .
Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F, Gusella J, Ramesh V (1998). "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins" . J. Biol. Chem . 273 (3): 1273–6. doi :10.1074/jbc.273.3.1273 . PMID 9430655 .
Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2" . J. Cell Biol . 140 (4): 885–95. doi :10.1083/jcb.140.4.885 . PMC 2141743 . PMID 9472040 .
PDB gallery
1e5w : STRUCTURE OF ISOLATED FERM DOMAIN AND FIRST LONG HELIX OF MOESIN
1ef1 : CRYSTAL STRUCTURE OF THE MOESIN FERM DOMAIN/TAIL DOMAIN COMPLEX
1j19 : Crystal structure of the radxin FERM domain complexed with the ICAM-2 cytoplasmic peptide
1sgh : Moesin FERM domain bound to EBP50 C-terminal peptide
2d10 : Crystal structure of the Radixin FERM domain complexed with the NHERF-1 C-terminal tail peptide
2d11 : Crystal structure of the Radixin FERM domain complexed with the NHERF-2 C-terminal tail peptide
2d2q : Crystal structure of the dimerized radixin FERM domain
2yvc : Crystal structure of the Radixin FERM domain complexed with the NEP cytoplasmic tail
This article incorporates text from the United States National Library of Medicine , which is in the public domain .