Nergal-sharezer or Neriglissar (in Akkadian Nergal-šar-uṣur, "Oh god Nergal, preserve/defend the king") was King of Babylon from 560 to 556 BC. He was the son-in-law of Nebuchadrezzar II, whose son and heir, Amel-Marduk, Nergal-sharezer murdered and succeeded. A Babylonian chronicle describes his western war in 557/556. He is traditionally listed as a king of the Chaldean Dynasty, however it is not known if he was a Chaldean or native of Babylon, as he was not related by blood to Nabopolassar and his successors. His name is mentioned as one of high-ranking officers of king Nebuchadnezzar II in the Bible (Jeremiah 39:13).

Preceded byAmel-Marduk King of Babylon 560–556 BC Succeeded byLabashi-Marduk