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Norman Henry Giles
Norman H. Giles
Born(1915-08-06)August 6, 1915
DiedOctober 16, 2006(2006-10-16) (aged 91)
Alma materEmory University (BA), Harvard University (PhD)
Known forMutations of Neurospora crassa
Awards
  • Lamar Dodd Award: University of Georgia (1985)
  • Thomas Hunt Morgan Medal (1988): Genetics Society of America
Scientific career
FieldsMicrobial genetics
InstitutionsYale University, University of Georgia

Norman Henry Giles (August 6, 1915 – October 16, 2006) was an American microbial geneticist who studied mutations of Neurospora crassa.

Norman H. Giles was a pioneer in genetics research. He was a member of the Botany Department at Yale University starting as an Instructor in Botany and rising to Professor of Biology (1951-1961). He then became Professor of Genetics (1961-1972). In 1972 Giles accepted a professorship at the University of Georgia where he established an active program in genetics that in 1980 became the Department of Genetics. He retired in 1986. Giles made important scientific contributions in the areas of intragenic complementation, gene conversion and analysis of gene clusters. His early work on intragenic complementation led to the insight that complementation between allelic mutants is of widespread occurrence and likely involves interactions occurring in the cytoplasm between defective gene products, that is between polypeptides.[1] This early insight led to numerous further studies of intragenic complementation that amplified this initial insight (see for example[2]).

Notable papers

Footnotes

  1. ^ Case ME, Giles NH. COMPARATIVE COMPLEMENTATION AND GENETIC MAPS OF THE PAN-2 LOCUS IN NEUROSPORA CRASSA. Proc Natl Acad Sci U S A. 1960 May;46(5):659-76. doi: 10.1073/pnas.46.5.659. PMID: 16590655; PMCID: PMC222889
  2. ^ CRICK FH, ORGEL LE. THE THEORY OF INTER-ALLELIC COMPLEMENTATION. J Mol Biol. 1964 Jan;8:161-5. doi: 10.1016/s0022-2836(64)80156-x. PMID: 14149958

References