Paul B. Sigler ((1934-02-19)February 19, 1934 – (2000-01-11)January 11, 2000^[7][1]) was the Henry Ford II Professor of Molecular Biophysics and Biochemistry at Yale University.^[3][8] Major awards included membership in the National Academy of Sciences, HHMI Investigator status, and Guggenheim^[2] and Helen Hay Whitney Fellowships.^[5] He is noted for pioneering studies of Phospholipase A2 and trp repressor amongst many others.^[1]

Biography

Prior to coming to Yale, he was a professor at the University of Chicago.^[2] He received his MD from Columbia University in 1959 and his undergraduate degree from Princeton University in 1955.^[2] After briefly practicing medicine and working as a researcher for the NIH,^[5] he would go on to earn a second doctorate, a PhD, from Cambridge University at the Laboratory of Molecular Biology^[2] working under David M. Blow^[6] before moving to the University of Chicago.^[2]

Memorials

A memorial plaque is located in front of the Bass Center for Structural Biology on Science Hill on the campus of Yale University. Yale has a Paul Sigler Memorial Prize for undergraduate research in Molecular Biophysics & Biochemistry.^[9] Yale also has sponsored Paul Sigler memorial symposia in the past.^[10] The Agouron Institute sponsored 12 Paul Sigler fellowships between 2000 and 2006.^[11]

Death

Paul Sigler died on January 11, 2000, at New Haven, Connecticut, US, about a month before his 66th birthday.^{[citation needed]}

Selected publications

• Lambright, David G.; Sondek, John; Bohm, Andrew; Skiba, Nikolai P.; Hamm, Heidi E.; Sigler, Paul B. (1996). "The 2.0 Å crystal structure of a heterotrimeric G protein". Nature. 379 (6563): 311–9. Bibcode:1996Natur.379..311L. doi:10.1038/379311a0. PMID 8552184. S2CID 4350943.
• Luisi, B. F.; Xu, W. X.; Otwinowski, Z.; Freedman, L. P.; Yamamoto, K. R.; Sigler, P. B. (1991). "Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA". Nature. 352 (6335): 497–505. Bibcode:1991Natur.352..497L. doi:10.1038/352497a0. PMID 1865905. S2CID 1919276.
• Braig, Kerstin; Otwinowski, Zbyszek; Hegde, Rashmi; Boisvert, David C.; Joachimiak, Andrzej; Horwich, Arthur L.; Sigler, Paul B. (1994). "The crystal structure of the bacterial chaperonln GroEL at 2.8 Å". Nature. 371 (6498): 578–86. Bibcode:1994Natur.371..578B. doi:10.1038/371578a0. PMID 7935790. S2CID 4341993.
• Kim, Youngchang; Geiger, James. H.; Hahn, Steven; Sigler, Paul B. (1993). "Crystal structure of a yeast TBP/TATA-box complex". Nature. 365 (6446): 512–20. Bibcode:1993Natur.365..512K. doi:10.1038/365512a0. PMID 8413604. S2CID 4336203.
• Vinson, C.; Sigler, P.; McKnight, S. (1989). "Scissors-grip model for DNA recognition by a family of leucine zipper proteins". Science. 246 (4932): 911–6. Bibcode:1989Sci...246..911V. doi:10.1126/science.2683088. PMID 2683088.
• Otwinowski, Z; Schevitz, R. W.; Zhang, R. G.; Lawson, C. L.; Joachimiak, A; Marmorstein, R. Q.; Luisi, B. F.; Sigler, P. B. (1988). "Crystal structure of trp repressor/operator complex at atomic resolution". Nature. 335 (6188): 321–9. Bibcode:1988Natur.335..321O. doi:10.1038/335321a0. PMID 3419502. S2CID 9358980.