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Names | |
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Other names
PRA
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Identifiers | |
3D model (JSmol)
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ChEBI | |
ChemSpider | |
MeSH | Phosphoribosylamine |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C5H12NO7P | |
Molar mass | 229.125 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Phosphoribosylamine (PRA) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA.[1][2][3] The vitamins thiamine[4] and cobalamin[5] also contain fragments derived from PRA.[6]
It is the product of the enzyme amidophosphoribosyltransferase which attaches ammonia from glutamine to phosphoribosyl pyrophosphate (PRPP) at its anomeric carbon:[2]
The biosynthesis pathway next combines PRA with glycine in a process driven by ATP giving glycineamide ribonucleotide (GAR). The enzyme phosphoribosylamine—glycine ligase catalyses the reaction forming an amide bond:[7]