Prohibition City is an unincorporated community in Worth County, in the U.S. state of Missouri.[1] In 1943 the Smithton School was adjacent to Missouri Route YY (at the time U. S. Route 169) approximately 1.5 miles northeast of Worth.[2]
An early variant name was "Smithton".[1] A settlement called Smithton served as county seat, but the town's population dwindled after the seat was removed to Grant City.[3] A post office called Smithton was established in 1861, and closed in 1870; the post office reopened as Prohibition City in 1877, and was discontinued in 1881.[4] A first settler's advocacy of prohibition politics caused the most recent name to be selected.[3]