Dr. Rick Lanman | |
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Born | Richard Burnham Lanman Jr. 1955 (age 68–69) |
Nationality | American |
Education | Stanford University, B.S. 1977 Northwestern University School of Medicine, M.D. 1980 |
Occupation(s) | Physician-scientist and Naturalist |
Years active | 1978-present |
Known for | Biomarkers in Cardiovascular disease and Cancer, and Historical ecology |
Relatives | Martha Lee Hopkins Struever (mother) Fritz Lanman (son) James Lanman (son) |
Medical career | |
Profession | Medical Doctor |
Institutions | Guardant Health, Inc. Veracyte, Inc. diaDexus, Inc. Atherotech, Inc. San Jose Medical Group, Inc. Kaiser Permanente |
Research | Cancer genomics, Precision oncology, Cardiovascular Biomarkers, Thyroid cancer, Interstitial lung disease, Psychiatry, Ecology |
Richard Burnham Lanman is an American biotechnology entrepreneur, physician scientist, and naturalist.[1] His contributions relate to improving diagnosis and utilization of less invasive medical procedures,[2][3] most recently as Global Chief Medical Officer at Guardant Health, Inc., a precision oncology company that developed a blood test replacing invasive tissue biopsies to sequence tumor DNA and improve cancer treatment selection.[4][5][6] Lanman has worked in five different medical specialties, oncology, cardiology, endocrinology, pulmonology, and psychiatry, as well as historical ecology, and has authored or co-authored 130 peer-reviewed scientific publications.[7]
Lanman was born at an U.S. Army Hospital in Frankfurt am Main, Hesse, Germany, in 1955. He is the son of American Indian art dealer and author Martha Lee Hopkins Lanman Struever and Lieutenant Richard Burnham Lanman Sr.[8] Lanman grew up in Munster, Indiana where his parents had a hardware store. At age 11, his father died from leukemia. Lanman graduated Phi Beta Kappa at Stanford University, with a B.S. in Chemistry in 1977.
After obtaining his M.D. from the Northwestern University School of Medicine in 1980, Lanman began his medical internship at Northwestern Memorial Hospital, then in July 1981 began another medical internship at the University of California San Francisco Moffit Hospital. From 1982 to 1985 he completed his residency in psychiatry at Langley Porter Psychiatric Institute, also at UCSF. He became a diplomate of the American Board of Psychiatry and Neurology in 1990. During medical school and residency, Lanman authored journal articles in cardiology and psychiatry,[9][10] including a book chapter.[11]
Lanman began his medical career as an attending psychiatrist at Kaiser Permanente in Santa Clara County, California in 1985, where he served as Chief of Psychiatry and Chemical Dependency, then, as Chief of Quality. At Kaiser Lanman encouraged adoption of less invasive procedures and improvements in diagnosis in other specialties, culminating in a book chapter he authored on variation in physician practice patterns and hospitalization rates for children with asthma across Kaiser's 14 hospitals in Northern California.[3]
Lanman left Kaiser Permanente to serve as Chief Medical Officer and Sr. Vice President at San Jose Medical Group (SJMG), in San Jose, California from 1993 to 1995, a large multispecialty physician group practice.[12][13][14][15] San Jose Medical Group was named the "most effective managed care medical group in the country" in 1996 by The Advisory Board Company.[16]
In 1995, Lanman founded Adesso Healthcare Technology Services as Founder and Chief Executive Officer.[17][18] Adesso offered an alternative to a cost-cutting approach by health maintenance organizations (HMOs) that had been using primary care physicians as gatekeepers, limiting access to specialty physician care.[19] Under Adesso, patients could be referred to specialist physician networks, such as cardiologists or ophthalmologists, without preauthorization. In return the specialist networks contracted directly with health insurers, and instead of fee-for-service, the specialists were reimbursed utilizing severity-adjusted case rates for each episode of care.[2][20] Adesso filed for an IPO in early 2000,[21] however, the public offering succumbed to the stock market crash that year.
Lanman transitioned to the biotechnology sector from physician practice management, first joining Atherotech, Inc. as Chief Medical Officer in 2000. Atherotech offered a cardiovascular biomarker diagnostic known as the Vertical Auto Profile- or VAP-expanded cholesterol and lipoprotein test, to improve prediction of risk of heart attack and stroke.[22][23][24][25][26] There he published validation studies on the VAP test's unique lipoprotein (a) (Lp(a)) cholesterol measurement and other lipoprotein biomarkers.[27] Atherotech was privately acquired by Behrman Capital.[28]
In 2005, Lanman joined a second preventive cardiology biomarker company, diaDexus, Inc., as Executive Vice President and Chief Medical Officer. DiaDexus developed a test for lipoprotein-associated phospholipase A2 (Lp-PLA2), the first FDA-cleared biomarker test to predict risk of stroke.[29][30][31] DiaDexus completed a reverse IPO via merger with VaxGen in 2010.[32]
After working in two companies to improve prediction of risk for cardiovascular events, Lanman joined Veracyte, Inc. in 2008 as Chief Medical Officer. Veracyte develops minimally invasive diagnostic tests utilizing genomics. Veracyte's initial genomics tests improved the diagnosis of thyroid nodules and lung nodules without resorting to surgery.[33][34] Lanman was also principal investigator in a study validating Veracyte's third genomics test to improve diagnosis of idiopathic pulmonary fibrosis versus other idiopathic interstitial pneumonias.[35] Veracyte, Inc. went public in October, 2013.[36]
In September 2014, Lanman joined Guardant Health, Inc. where he served as Global Chief Medical Officer.[6] Guardant's first diagnostic test, Guardant360® enabled sequencing of the DNA in patients' advanced cancers with a simple blood test, as an aid in treatment selection for targeted therapy or immunotherapy without requiring invasive tissue biopsies.[4] This non-invasive test was approved by Medicare to help identify targetable mutations in most solid tumor cancers in 2019.[37] Guardant Health went public in October, 2018.[38]
Lanman researches and publishes on California's historical ecology to improve and guide efforts at rewilding, often changing understanding of the historical fauna and flora of the state.[39] His first historical ecology discovery was of lost specimens of steelhead trout (Oncorhynchus mykiss) in the collections of the California Academy of Sciences, establishing that in the 1890's the creek behind his house in Los Altos was a trout stream.[40] Next, in a trio of publications, he and colleagues established novel physical evidence that the North American beaver (Castor canadensis) was native to most of California.[41][42][43][1] A fourth publication reported the last record of beaver in the San Francisco Bay Area prior to their extirpation from the fur trade in the form of rock art, known as "Western Message Petroglyphs", which describe a vacant beaver lodge in the Alameda Creek watershed.[44] In 2021, Lanman and colleagues published the results of an ancient DNA sequencing study of salmonid remains from archaeological excavations at Mission Santa Clara which extended the southern limit of the historical spawning range of Chinook salmon, 120 kilometres (75 mi) further south to San Jose, California.[45] More recently, he proposed, along with the Muwekma Ohlone and Amah Mutsun tribes, restoration of tule elk (Cervus canadensis nannodes) to the San Francisco Peninsula and northern Monterey Bay regions.[46] In 2023, he published, along with California Department of Fish and Wildlife (CDFW) and University of California, Berkeley biologists, a habitat suitability analysis which found long patches of habitat suitable for tule elk from Pacifica to the Pajaro River along the coastal and inland sides of the Santa Cruz Mountains.[47]
Lanman retired from Guardant Health on December 31, 2019, but continued as an Advisor through early 2021. He continues to research and publish in medicine and historical ecology, while also serving on the Boards of TwiXimo, Inc., Circulogene, Inc., WeTree, Inc., and as an Advisor to Forward Health, Inc., Glympse Bio, Inc., Precede Biosciences, and Teiko Bio, Inc. He was a past Board member of Biolase, Inc. from 2017–2022 and the American Psychiatric Association from 1983–1985.[48][49]
Lanman married Alanna Purcell in 1978 and they raised five sons in Los Altos, California.[55]