Saint Charles may refer to:

People

Charles I, Count of Flanders (1084–1127), Blessed Charles the Good, count of Flanders, 1119–1127
Charles, Duke of Brittany (1319–1364), Blessed Charles de Châtillon
Saint Charles Borromeo (1538–1584), cardinal and archbishop of Milan, 1564–1584
Blessed Charles Spinola (1564–1622), Italian Jesuit missionary martyred in Japan
King Charles the Martyr (1600–1649), Canonized Anglican Saint and martyr, king of England, Scotland, and Ireland, 1625–1649
Saint Charles Garnier (missionary) (1606–1649), French Jesuit missionary martyred in Canada
Saint Charles of Sezze (1613–1670), Italian friar of the Franciscan Order
Saint Charles-Joseph-Eugène de Mazenod (1782–1861), French Catholic clergyman
Saint Charles of Mount Argus (1821–1893), Dutch Passionist priest who worked in Ireland
Saint Charles Lwanga (1860 or 1865–1886), Ugandan Catholic martyr

Places

Saint-Charles Parish, New Brunswick
- Saint-Charles, New Brunswick, an unincorporated community
St. Charles, Ontario, town in the Sudbury District
St. Charles, Winnipeg, city ward of Winnipeg, Manitoba
Saint-Charles-Borromée, Quebec, city in the region of Lanaudière
Saint-Charles-sur-Richelieu, Quebec, municipality in La Vallée-du-Richelieu Regional County Municipality
Pointe-Saint-Charles, neighborhood in Le Sud-Ouest, Montreal, Quebec

Saint-Charles-de-Percy, merged into Valdallière commune in Calvados department, Normandy region
Marseille-Saint-Charles Station, main railway station and intercity bus station, Marseille, Bouches-du-Rhône

St. Charles, Arkansas, town in Arkansas County
Saint Charles Reservoir, in Pueblo County, Colorado
Saint Charles River, in Colorado
Saint Charles, Georgia
St. Charles, Idaho, city in Bear Lake County
St. Charles, Illinois, city in DuPage and Kane counties
St. Charles, Iowa, city in Madison County
St. Charles, Kentucky, city in Hopkins County
St. Charles Parish, Louisiana, parish in New Orleans metropolitan area
St. Charles, Maryland, planned community in Charles County
St. Charles, Michigan, village in Saginaw County
St. Charles, Minnesota, city in Winona County
St. Charles County, Missouri, county in eastern Missouri
- St. Charles, Missouri, city and county seat
Saint Charles, Ohio, unincorporated community in Butler County
St. Charles, South Carolina, census-designated place in Lee County
St. Charles, South Dakota, census-designated place in Gregory County
St. Charles, Virginia, census-designated place in Lee County

Saint Charles Preparatory School, Catholic high school in Columbus, Ohio, United States
St. Charles Parish Public School System, public school district headquartered in Luling, Louisiana
St. Charles Borromeo School, private catholic school in Destrehan, Louisiana
St. Charles Borromeo High School, former private high school in Destrehan, Louisiana
St. Charles Catholic High School (Laplace, Louisiana), private high school in the Archdiocese of New Orleans
St. Charles Community Schools, school district in St. Charles, Michigan
St. Charles East High School, public high school in St. Charles, Illinois
St. Charles Garnier College, private secondary school in Quebec City, Quebec
St Charles' Primary School, primary school in Newton, Scotland
Saint-Charles International School, private boarding school in Porrentruy, Ajoie in the Swiss Canton of Jura

St. Charles (ship), screw-driven steamboat on the upper Peace River, Canada, 1903–1916
St. Charles Streetcar Line, Louisiana, U.S.