Protein-coding gene in the species Homo sapiens
UBA3 |
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![](https://upload.wikimedia.org/wikipedia/commons/thumb/3/34/Protein_UBE1C_PDB_1r4m.png/250px-Protein_UBE1C_PDB_1r4m.png) |
Available structures |
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PDB | Ortholog search: PDBe RCSB |
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List of PDB id codes |
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1R4M, 1R4N, 1TT5, 1Y8X, 1YOV, 2LQ7, 2NVU, 3DBH, 3DBL, 3DBR, 3FN1, 3GZN |
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Identifiers |
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Aliases | UBA3, NAE2, UBE1C, hubiquitin like modifier activating enzyme 3 |
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External IDs | OMIM: 603172; MGI: 1341217; HomoloGene: 2951; GeneCards: UBA3; OMA:UBA3 - orthologs |
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Wikidata |
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NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.[5][6]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]
This enzyme contains an E2 binding domain, which resembles ubiquitin, and recruits the catalytic core of the E2 enzyme UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.[7]
Interactions
UBE1C has been shown to interact with NEDD8,[8] APPBP1[9] and UBE2M.[7]