Pacific-12 Conference (forkortet PAC-12) er en amerikansk sportsliga bestående af de 12 største universiteter i staterne Washington, Oregon, Californien og Arizona, Colorado og Utah.

Ligaen har oprindeligt heddet Big Five, Big Six, Pacific-8 og Pacific-10 alt efter hvor mange universiteter, der deltog. Da ligaen hed Pacific-10 var deltagerne:

University of Arizona, Tucson, Arizona, Arizona Wildcats
Arizona State University, Tempe, Arizona, Arizona State Sun Devils
University of California, Berkeley, Californien, California Golden Bears
University of Oregon, Eugene, Oregon, Oregon Ducks
Oregon State University, Corvallis, Oregon, Oregon State Beavers

Stanford University, Stanford, Californien, Stanford Cardinals
University of California, Los Angeles, Californien, UCLA Bruins
University of Southern California, Los Angeles, Californien, USC Trojans
University of Washington, Seattle, Washington, Washington Huskies
Washington State University, Pullman, Washington, Washington State Cougars

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