Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Comedy Series er en award, som uddeles af Screen Actors Guild for at ære den flotteste skuespiller-præsentation, som bedste kvindelige skuespiller i en komedie-serie.
1994: Helen Hunt, Mad About You
1995: Christine Baranski, Cybill
1996: Julia Louis-Dreyfus, Seinfeld
1997: Julia Louis-Dreyfus, Seinfeld
1998: Tracey Ullman, Tracey Takes On...
1999: Lisa Kudrow, Friends
2000: Sarah Jessica Parker, Sex and the City
2001: Megan Mullally, Will & Grace
2002: Megan Mullally , Will & Grace
2003: Megan Mullally, Will & Grace
2004: Teri Hatcher, Desperate Housewives
2005: Felicity Huffman, Desperate Housewives
2006: America Ferrera, Ugly Betty
2007: Tina Fey, 30 Rock
2010 – Betty White – Hot in Cleveland som Elka Ostrovsky
2011 – Betty White – Hot in Cleveland som Elka Ostrovsky