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January 22 – The Overseas Railroad opens: the first train arrives in Key West, Florida, at 10:43 a.m. with Henry M. Flagler, the railroad's creator and owner, aboard.
February
February 14 – Arizona is admitted as the 48th U.S. state and the last of contiguous states to be admitted into the Union (seeHistory of Arizona).
March 27 – Mayor Yukio Ozaki of Tokyo gives 3,000 cherry blossom trees to be planted in Washington, D.C., to symbolize the friendship between the two countries.
April 10 – The British ocean linerRMS Titanic leaves Southampton, England on her maiden voyage for New York City.
April 14–15 – Sinking of the RMS Titanic: RMS Titanic strikes an iceberg in the northern Atlantic Ocean and sinks with the loss of between 1,517 and 1,636 lives. The wreck will not be discovered until 1985.[2]
April 19 – The United States Senate initiates an official inquiry into the Titanic disaster, hastily issuing subpoenas for White Star personnel before they can return to the United Kingdom.
May 18 – The Detroit Tigers go on strike to protest the suspension of Ty Cobb. A replacement team recruited from the coaching staff and local colleges is fielded to avoid a forfeiture to the Philadelphia A's in a lopsided loss.
June 8 – Carl Laemmle founds Universal Studios as the Universal Film and Manufacturing Company in New York City, moving production to Hollywood by the end of the year
July 19 – A meteorite with an estimated mass of 190 kg explodes over the town of Holbrook in Navajo County, Arizona causing thousands of pieces of debris to rain down on the town.
October 14 – While campaigning in Milwaukee, Wisconsin, former President Theodore Roosevelt is shot by saloonkeeper John Schrank. With a fresh flesh wound and the bullet still in him, Roosevelt delivers his scheduled speech. After finishing it, he goes to the hospital, where it is deduced that if he had not had his speech in his breast pocket when he was shot, he most likely would have died.
October 16 – The Boston Red Sox, assisted by a famous error, defeat the New York Giants in extra innings to win the 1912 World Series in what is considered one of the greatest games of baseball ever played.