There were special elections to the U.S. House of Representatives in 1921.
| District | Incumbent | This race | |||
|---|---|---|---|---|---|
| Member | Party | First elected | Results | Candidates | |
| Alabama 4 | Fred Blackmon | Democratic | 1910 | Incumbent died February 8, 1921. New member elected June 7, 1921. Democratic hold. |
|
| Arkansas 6 | Samuel M. Taylor | Democratic | 1912 | Incumbent died September 13, 1921. New member elected October 25, 1921. Democratic hold. |
|
| California 9 | Vacant | Representative-elect Charles F. Van de Water (R) died November 20, 1920. New member elected February 15, 1921. Republican hold. |
| ||
| Iowa 5 | James W. Good | Republican | 1908 | Incumbent resigned June 15, 1921. New member elected. Republican hold. |
|
| Massachusetts 6 | Willfred W. Lufkin | Republican | 1917 | Incumbent resigned June 30, 1921. New member elected. Republican hold. |
|
| Michigan 3 | William H. Frankhauser | Republican | 1920 | Incumbent died May 9, 1921. New member elected June 28, 1921. Republican hold. |
|
| Pennsylvania at-large | Mahlon Morris Garland | Republican | 1914 | Incumbent died November 19, 1921. New member elected September 20, 1921. Republican hold. |
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