The 1945 All-Big Six Conference football team consists of American football players chosen by various organizations for All-Big Six Conference teams for the 1945 college football season. The selectors for the 1945 season included the Associated Press (AP).

All-Big Six selections

Backs

• Leonard Brown, Missouri (AP-1)
• Richard Howard, Iowa State (AP-1)
• John West, Oklahoma (AP-1)
• Jack Venable, Oklahoma (AP-1)
• Alvin Bandy, Kansas State (AP-2)
• Robert Hopkins, Missouri (AP-2)
• Gene Phelps, Iowa State (AP-2)
• Gerald Moore, Nebraska (AP-2)

Ends

• Roland Oakes, Missouri (AP-1)
• David Schmidt, Kansas (AP-1)
• Omer Burgert, Oklahoma (AP-2)
• Aubrey McCall, Oklahoma (AP-2)

Tackles

• Jim Kekeris, Missouri (AP-1)
• Thomas Tallchief, Oklahoma (AP-1)
• Richard Cole, Iowa State (AP-2)
• John Sedlacek, Nebraska (AP-2)

Guards

• Jack Fathauer, Iowa State (AP-1)
• Thurman Tigart, Oklahoma (AP-1)
• Robert Eigelberger, Missouri (AP-2)
• Russell Hardin, Kansas State (AP-2)

Centers

• Ralph Stewart, Missouri (AP-1)
• James Riding, Iowa State (AP-2)

Key

AP = Associated Press^[1]