The 1949 All-Big Six Conference football team consists of American football players chosen by various organizations for All-Big Six Conference teams for the 1949 college football season. The selectors for the 1949 season included the Associated Press (AP) and United Press (UP). Players who were the consensus first-team selection of both the AP and UP are shown in bold.

All-Big Seven selections

Backs

• Darrell Royal, Oklahoma (AP-1; UP-1 [QB]) (College Football Hall of Fame)
• George Thomas, Oklahoma (AP-1; UP-1)
• Dick Braznell, Missouri (AP-1; UP-1)
• Bill Weeks, Iowa State (AP-1)
• John Glorioso, Missouri (AP-2; UP-1)
• Lindell Pearson, Oklahoma (AP-2)
• Bud French, Kansas (AP-2)
• Leon Heath, Oklahoma (AP-2)

Ends

• Jim Owens, Oklahoma (AP-1; UP-1)
• Jim Doran, Iowa State (AP-1; UP-1)
• Gene Ackerman, Missouri (AP-2)
• Bobby Goad, Oklahoma (AP-2)

Tackles

• Wade Walker, Oklahoma (AP-1; UP-1)
• Charlie Toogood, Nebraska (AP-1; UP-1)
• Leon Manley, Oklahoma (AP-2)
• Peter Thompson, Colorado (AP-2)

Guards

• Stan West, Oklahoma (AP-1; UP-1)
• Dick Tomlinson, Kansas (AP-1; UP-1)
• Gene Pepper, Missouri (AP-2)
• Dee Andros, Oklahoma (AP-2)

Centers

• Tom Novak, Nebraska (AP-1; UP-1)
• Robert Fuchs, Missouri (AP-2)

Key

AP = Associated Press^[1]

UP = United Press^[2]