The 1958 Xavier Musketeers football team competed in the 1958 NCAA College Division football season as an independent for Xavier University. The team was coached by Harry Connolly and played their home games at Xavier Stadium in Cincinnati, Ohio.

Schedule

Date	Time	Opponent	Site	Result	Attendance	Source
September 14	8:00 p.m.	Saint Joseph's (IN)	Xavier Stadium Cincinnati, OH	W 8–0	11,500	[1][2]
September 20	2:00 p.m.	Kent State	Xavier Stadium Cincinnati, OH	L 0–6	7,500	[3][4]
September 28	8:00 p.m.	Quantico Marines	Xavier Stadium Cincinnati, OH	L 20–31	7,000	[5][6]
October 4	2:00 p.m.	at No. 5 Miami (OH)	Miami Field Oxford, OH	W 22–8	9,519	[7][8]
October 11	2:00 p.m.	at Cincinnati	Nippert Stadium Cincinnati, OH	L 8–14		[9][10]
October 18	2:00 p.m.	Detroit	Xavier Stadium Cincinnati, OH	L 6–31	9,000	[11][12]
October 25	8:00 p.m.	Dayton	Xavier Stadium Cincinnati, OH	W 16–0	6,500	[13][14]
November 1	2:00 p.m.	at Marshall	Fairfield Stadium Huntington, WV	W 14–6	3,500	[15][16]
November 8	8:15 p.m.	Toledo	Glass Bowl Toledo, OH	W 34–8		[17][18]
November 15	2:00 p.m.	at Kentucky	McLean Stadium Lexington, KY	L 6–20	25,000	[19][20]
Homecoming Rankings from UPI Poll released prior to the game All times are in Eastern time