The 1959 Duke Blue Devils football team was an American football team that represented Duke University as a member of the Atlantic Coast Conference (ACC) during the 1959 NCAA University Division football season. In their ninth year under head coach William D. Murray, the Blue Devils complied an overall record of 4–6, with a conference record of 2–3, and finished sixth in the ACC.

Schedule

Date	Opponent	Site	Result	Attendance	Source
September 19	at South Carolina	Carolina Stadium Columbia, SC	L 7–12	37,000	[1]
September 26	at No. 12 Ohio State*	Ohio Stadium Columbus, OH	L 13–14	82,834	[2]
October 3	Rice*	Duke Stadium Durham, NC	W 24–7	21,000	[3]
October 10	at Pittsburgh*	Pitt Stadium Pittsburgh, PA	L 0–12	38,749	[4]
October 17	Army*	Duke Stadium Durham, NC	L 6–21	33,500	[5]
October 24	at NC State	Riddick Stadium Raleigh, NC (rivalry)	W 17–15	14,000	[6]
October 31	at No. 9 Georgia Tech*	Grant Field Atlanta, GA	W 10–7	44,174	[7]
November 7	at No. 10 Clemson	Memorial Stadium Clemson, SC	L 0–6	40,000	[8]
November 14	Wake Forest	Duke Stadium Durham, NC (rivalry)	W 27–15	25,000	[9]
November 21	North Carolina	Duke Stadium Durham, NC (Victory Bell)	L 0–50	33,000	[10]
*Non-conference game Homecoming Rankings from AP Poll released prior to the game

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