The 1959 Southern Illinois Salukis football team was an American football team that represented Southern Illinois University (now known as Southern Illinois University Carbondale) in the Interstate Intercollegiate Athletic Conference (IIAC) during the 1959 NCAA College Division football season. Under first-year head coach Carmen Piccone, the team compiled a 5–4 record.^[1] The team played its home games at McAndrew Stadium in Carbondale, Illinois.

Schedule

Date	Opponent	Site	Result	Attendance	Source
September 19	at Evansville*	Reitz Bowl Evansville, IN	L 8–20	5,300
September 26	at West Virginia State*	Charleston, WV	W 20–6	1,400	[2]
October 3	Northern Illinois	McAndrew Stadium Carbondale, IL	L 15–20	7,000
October 10	at No. T–18 Western Illinois	Hanson Field Macomb, IL	L 6–33	4,300	[3]
October 17	Eastern Illinois	McAndrew Stadium Carbondale, IL	W 7–0	11,500–13,000	[4]
October 24	at Illinois State Normal	McCormick Field Normal, IL	W 19–8	3,000
October 30	at Eastern Michigan	Briggs Field Ypsilanti, MI	W 41–14	600
November 7	No. 4 Bowling Green*	McAndrew Stadium Carbondale, IL	L 14–23	5,500	[5]
November 14	Central Michigan	McAndrew Stadium Carbondale, IL	W 51–20	2,000–3,000	[6]
*Non-conference game Homecoming Rankings from UPI Poll released prior to the game

^[7]