The second 1961 Major League Baseball All-Star Game was played in Fenway Park in Boston on July 31, 1961. It was the first MLB All-Star Game to end in a tie. The game in 2002 also ended in a tie.
Rocky Colavito's one-out home run in the bottom of the first off National League starter Bob Purkey gave the American League a 1–0 lead, but Purkey only allowed two walks in the second before Art Mahaffey pitched a scoreless third and fourth, allowing only a leadoff walk to Mickey Mantle in the fourth. The Americans only got three more hits versus Sandy Koufax and Stu Miller.
American starter Jim Bunning pitched three perfect innings, but Don Schwall allowed a bases-loaded single to Bill White that tied the game in the sixth. All five hits the Nationals got were charged to Schwall. Camilo Pascual pitched three shutout innings before the game was called due to rain after nine innings with the score 1–1.
Players in italics have since been inducted into the National Baseball Hall of Fame.
Umpires: Larry Napp, Home Plate (AL); Frank Secory, First Base (NL); Red Flaherty, Second Base (AL); Ed Sudol, Third Base (NL); Al Smith, Left Field (AL); Chris Pelekoudas, Right Field (NL)