The second election to Lothian Regional Council was held on 2 May 1978 and saw Labour gaining a majority of the council's 49 seats amidst a Labour surge across Scotland. Stephen Maxwell, the SNP's vice-chairman, was a prominent victim of the Labour gains, losing his seat of Slateford/Hailes.
|Party||Seats||Gains||Losses||Net gain/loss||Seats %||Votes %||Votes||+/−|
|Labour||J. P. Mulvey||2,272||39.23|
|Labour gain from SNP|