The 1999 All-Big 12 Conference football team consists of American football players chosen as All-Big 12 Conference players for the 1999 NCAA Division I-A football season. The conference recognizes two official All-Big 12 selectors: (1) the Big 12 conference coaches selected separate offensive and defensive units and named first- and second-team players (the "Coaches" team);^[1] and (2) a panel of sports writers and broadcasters covering the Big 12 also selected offensive and defensive units and named first- and second-team players (the "Media" team).^[2]

Offensive selections

Quarterbacks

• Major Applewhite, Texas (Coaches-1 (tie); Media-1)
• Eric Crouch, Nebraska (Coaches-1 (tie); Media-2)
• Josh Heupel, Oklahoma (Coaches-2)

Running backs

• Darren Davis, Iowa State (Coaches-1; Media-1)
• Hodges Mitchell, Texas (Coaches-1; Media-1)
• Sammy Morris, Texas Tech (Coaches-2)
• Cortlen Johnson, Colorado (Coaches-2)

Centers

• Rob Riti, Missouri (Coaches-1; Media-1)
• Dominic Raiola, Nebraska (Coaches-1)

Guards

Tackles

• Ryan Johanningmeier, Colorado (Coaches-1)

Tight ends

• Tracey Wistrom, Nebraska (Coaches-1; Media-1)
• Marcellus Rivers, Oklahoma State (Coaches-2)

Receivers

• Quincy Morgan, Kansas State (Coaches-1; Media-1)
• Kwame Cavil, Texas (Coaches-1; Media-1)

Defensive selections

Defensive linemen

• Darren Howard, Kansas State (Coaches-1; Media-1)
• Justin Smith, Missouri (Coaches-1; Media-1)
• Steve Warren, Nebraska (Coaches-1; Media-1)
• Casey Hampton, Texas (Coaches-1; Media-1)
• Shaun Rogers, Texas (Coaches-1)
• Aaron Humphrey, Texas (Coaches-2)
• Taurus Rucker, Texas Tech (Coaches-2)
• Justin Bannan, Colorado (Coaches-2)
• Mario Fatafehi, Kansas State (Coaches-2)
• Kris Kocurek, Texas Tech (Coaches-2)

Linebackers

• Carlos Polk, Nebraska (Coaches-1; Media-1)
• Mark Simoneau, Kansas State (Coaches-1; Media-1)
• Rocky Calmus, Oklahoma (Coaches-2; Media-1)
• Jashon Sykes, Colorado (Coaches-2; Media-1)

Defensive backs

• Mike Brown, Nebraska (Coaches-1; Media-1)
• Ralph Brown, Nebraska (Coaches-1; Media-1)
• Lamar Chapman, Kansas State (Coaches-1; Media-1)
• Carl Nesmith, Kansas (Coaches-1)
• Ben Kelly, Colorado (Media-1)
• Damen Wheeler, Colorado (Coaches-2)
• Jarrod Cooper, Kansas State (Coaches-2)
• Jason Webster, Texas A&M (Coaches-2)
• Kevin Curtis, Texas Tech (Coaches-2)

Special teams

Kickers

• Jamie Rheem, Kansas State (Coaches-1; Media-1)
• Kris Stockton, Texas (Coaches-2)

Punters

• Shane Lechler, Texas A&M (Coaches-1; Media-1)
• Dan Hadenfeldt, Nebraska (Coaches-2)

All-purpose / Return specialists

• David Allen, Kansas State (Coaches-1; Media-1)
• Ben Kelly, Colorado (Coaches-1)
• Bobby Newcombe, Nebraska (Coaches-2)
• Brandon Daniels, Oklahoma (Coaches-2)

Key