|CompTox Dashboard (EPA)|
|Chemical and physical data|
|Molar mass||213.252 g·mol−1|
|3D model (JSmol)|
|NY (what is this?)|
2,5-Dimethoxy-4-fluoroamphetamine (DOF) is a psychedelic drug of the phenethylamine and amphetamine classes. Alexander Shulgin briefly describes DOF in his book PiHKAL:
Animal studies that have compared DOF to the highly potent DOI and DOB imply that the human activity will be some four to six times less than these two heavier halide analogues.
DOF showed some stimulating effects in humans, but no psychedelic activity, after three doses of 6 mg spaced by one hour. Daniel Trachsel[who?] further suspected that the molar refraction of the important 4-substituent in DOF and 2C-F may be too low to activate the 5-HT2A receptor sufficiently. DOF more closely mimics the effects of the 4-unsubstituted 2,5-dimethoxyamphetamine than the effects of DOC, DOB, and DOI.
(and close relatives)