|Preferred IUPAC name
2-Aminoethyl diphenyl borate
Diphenylborinic acid 2-aminoethyl ester
3D model (JSmol)
CompTox Dashboard (EPA)
|Molar mass||225.10 g·mol−1|
|Melting point||192 to 194 °C (378 to 381 °F; 465 to 467 K)|
|Boiling point||325.3 °C (617.5 °F; 598.5 K) at 760mmHg|
|GHS Signal word||Warning|
|H302, H315, H319, H335|
|P261, P264, P270, P271, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P403+233, P405, P501|
|Flash point||150.6 °C (303.1 °F; 423.8 K)|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|what is ?)(|
2-Aminoethoxydiphenyl borate (2-APB) is a chemical that acts to inhibit both IP3 receptors and TRP channels (although it activates TRPV1, TRPV2, & TRPV3 at higher concentrations). In research it is used to manipulate intracellular release of calcium ions (Ca2+) and modify TRP channel activity, although the lack of specific effects make it less than ideal under some circumstances. Additionally, there is evidence that 2-APB acts directly to inhibit gap junctions made of connexin. Increasing evidence showed that 2-APB is a powerful modifier of store-operated calcium channels (SOC) function, low concentration of 2-APB can enhance SOC while high concentration induces a transient increase followed by complete inhibition.