The 2000 North Dakota State Bison football team was an American football team that represented North Dakota State University during the 2000 NCAA Division II football season as a member of the North Central Conference. In their fourth year under head coach Bob Babich, the team compiled a 12–2 record.

Schedule

Date	Opponent	Rank	Site	Result	Source
August 31	No. 10 Texas A&M–Kingsville*	No. 3	Fargodome Fargo, ND	W 52–7	[1]
September 9	Minnesota State–Moorhead*	No. 3	Fargodome Fargo, ND	W 80–0	[2]
September 16	at St. Cloud State	No. 3	Selke Field St. Cloud, MN	W 37–7	[3]
September 23	South Dakota	No. 3	Fargodome Fargo, ND	W 45–10	[4]
September 30	No. 3 (Midwest) North Dakota	No. 2 (Midwest)	Fargodome Fargo, ND (Nickel Trophy)	W 16–13	[5]
October 7	at Augustana (SD)	No. 2 (Midwest)	Howard Wood Field Sioux Falls, SD	W 24–20	[6]
October 14	No. 5 (Midwest) South Dakota State	No. 2 (Midwest)	Fargodome Fargo, ND (rivalry)	W 21–3	[7]
October 21	at No. 4 (Midwest) Nebraska–Omaha	No. 2 (Midwest)	Al F. Caniglia Field Omaha, NE	L 3–6	[8]
October 28	at Minnesota State	No. 3 (Midwest)	Blakeslee Stadium Mankato, MN	W 41–28	[9]
November 4	Northern Colorado	No. 3 (Midwest)	Fargodome Fargo, ND	W 38–14	[10]
November 11	Morningside	No. 3 (Midwest)	Fargodome Fargo, ND	W 55–14	[11]
November 18	at No. 1 (Midwest) Northwest Missouri State*	No. 3 (Midwest)	Bearcat Stadium Maryville, MO (NCAA Division II First Round)	W 31–17	[12]
November 25	at No. 2 (Midwest) Nebraska–Omaha	No. 3 (Midwest)	Al F. Caniglia Field Omaha, NE (NCAA Division II Quarterfinal)	W 43–21	[13]
December 2	at No. 5 (South) Delta State*	No. 3 (Midwest)	McCool Stadium Cleveland, MS (NCAA Division II Semifinal)	L 16–34	[14]
*Non-conference game Homecoming Rankings from AFCA Poll released prior to the game