The 2000 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) in the college football season of 2000, and was the tenth team fielded by the school. The Blazers' head coach was Watson Brown, who entered his sixth season as UAB's head coach. They played their home games at Legion Field in Birmingham, Alabama, and competed as a member of Conference USA. The Blazers finished their fifth season at the I-A level, and their second affiliated with a conference with a record of 7–4 (3–4 C-USA).

Schedule

Date	Time	Opponent	Site	TV	Result	Attendance	Source
September 7	7:00 p.m.	Chattanooga*	Legion Field Birmingham, AL	CSS	W 20–15	18,000	[1]
September 16	7:00 p.m.	at Kansas*	Memorial Stadium Lawrence, KS		L 20–23	28,500	[2]
September 23	7:00 p.m.	at LSU*	Tiger Stadium Baton Rouge, LA	WABM	W 13–10	85,339	[3]
September 30	2:30 p.m.	Louisiana–Lafayette*	Legion Field Birmingham, AL		W 47–2	22,000	[4]
October 7	2:30 p.m.	Louisville	Legion Field Birmingham, AL		L 17–38	18,000	[5]
October 14	2:30 p.m.	Memphis	Legion Field Birmingham, AL (Battle for the Bones)		W 13–9	15,000	[6]
October 21	3:00 p.m.	Middle Tennessee*	Legion Field Birmingham, AL	CSS	W 14–9	13,000	[7]
October 28	2:30 p.m.	at East Carolina	Dowdy–Ficklen Stadium Greenville, NC	WABM	W 16–13	28,537	[8]
November 4	12:00 p.m.	at Cincinnati	Nippert Stadium Cincinnati, OH		L 21–33	19,581	[9]
November 11	2:30 p.m.	No. 25 Southern Miss	Legion Field Birmingham, AL		L 30–33 OT	25,000	[10]
November 18	12:00 p.m.	at Army	Michie Stadium West Point, NY		W 27–7	35,267	[11]
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time