The 2001 Southern Illinois Salukis football team represented Southern Illinois University as a member of the Gateway Football Conference during the 2001 NCAA Division I-AA football season. They were led by first-year head coach Jerry Kill and played their home games at McAndrew Stadium in Carbondale, Illinois. The Salukis finished the season with a 1–10 record overall and a 1–6 record in conference play.^[1]

Schedule

Date	Opponent	Site	Result	Attendance	Source
September 8	at Southeast Missouri State*	Houck Stadium Cape Girardeau, MO	L 5–24	9,822	[2]
September 15	at Ball State*	Ball State Stadium Muncie, IN	Canceled		[3]
September 22	Murray State*	McAndrew Stadium Carbondale, IL	L 20–24	11,675	[4]
September 29	at No. 13 Western Illinois	Hanson Field Macomb, IL	L 21–38	13,744	[5]
October 6	Illinois State	McAndrew Stadium Carbondale, IL	W 23–17	9,830	[6]
October 13	at No. 15 Northern Iowa	UNI-Dome Cedar Falls, IA	L 14–19	13,455	[7]
October 20	No. 9 Eastern Illinois*	McAndrew Stadium Carbondale, IL	L 21–49	5,150	[8]
October 27	at Indiana State	Memorial Stadium Terre Haute, IN	L 14–20	4,533	[9]
November 3	No. 10 Youngstown State	McAndrew Stadium Carbondale, IL	L 7–31	2,090	[10]
November 10	Southwest Missouri State	McAndrew Stadium Carbondale, IL	L 24–25	2,140	[11]
November 17	at No. 12 Western Kentucky	L. T. Smith Stadium Bowling Green, KY	L 6–36	5,800	[12]
November 24	at Baylor*	Floyd Casey Stadium Waco, TX	L 12–56	7,321	[13]
*Non-conference game Homecoming Rankings from The Sports Network Poll released prior to the game