2001 Sybase Open
Date	February 26 – March 4
Edition	113th
Category	International Series
Draw	32S / 16D
Prize money	$375,000
Surface	Hard court / indoor
Location	San Jose, U.S.
Venue	Compaq Center
Champions
Singles
Greg Rusedski[1]
Doubles
Mark Knowles / Brian MacPhie[2]
← 2000 · Pacific Coast Championships · 2002 →

The 2001 Sybase Open was a men's tennis tournament played on indoor hard courts at the Compaq Center at San Jose in San Jose, California in the United States that was part of the International Series of the 2001 ATP Tour. It was the 113th edition of the tournament and was held from February 26 through March 4, 2001. Eighth-seeded Greg Rusedski won the singles title.

Finals

Singles

Greg Rusedski defeated Andre Agassi 6–3, 6–4

• It was Rusedski's only title of the year and the 13th of his career.

Doubles

Mark Knowles / Brian MacPhie defeated Jan-Michael Gambill / Jonathan Stark 6–3, 7–6^(7–4)

• It was Knowles' 2nd title of the year and the 16th of his career. It was MacPhie's 1st title of the year and the 3rd of his career.