The forty-sixth edition of the Caribbean Series (Serie del Caribe) was held from February 1 through February 6 of 2004 with the champion baseball teams of the Dominican Republic, Tigres del Licey; Mexico, Tomateros de Culiacán; Puerto Rico, Leones de Ponce, and Venezuela, Tigres de Aragua. The format consisted of 12 games, each team facing the other teams twice, and the games were played at Estadio Quisqueya in Santo Domingo, Dominican Republic.
| Country | Club | W | L | W/L % | Managers |
 Dominican Republic |
Tigres del Licey | 5 | 1 | .833 | Manny Acta |
 Mexico |
Tomateros de Culiacán | 4 | 2 | .667 | Francisco Estrada |
.svg){kind=small} Venezuela |
Tigres de Aragua | 3 | 3 | .500 | Buddy Bailey |
 Puerto Rico |
Leones de Ponce | 0 | 6 | .000 | José Cruz |
| Player | Statistic | ||||
| Batting | |||||
| Carlos Rivera (PUR) | Batting average | .391 | |||
| Raúl González (PUR) Luis López (PUR) Eduardo Ríos (VEN) |
Home runs | 2 | |||
| Luis López (PUR) José Offerman (DOM) Luis Ordaz (VEN) Kit Pellow (MEX) Robert Pérez (VEN) Luis Rodríguez (VEN) |
RBI | 5 | |||
| Pitching | |||||
| Twelve players tied | Wins | 1 | |||
| José Jiménez (DOM) | ERA | 0.00 | |||
| Francis Beltrán (DOM) | Saves | 3 | |||
| Name | Position | ||||
| Adán Amezcua (MEX) | Catcher | ||||
| Carlos Rivera (PUR) | First baseman | ||||
| Luis Rodríguez (VEN) | Second baseman | ||||
| Eduardo Ríos (VEN) | Third baseman | ||||
| Benji Gil (MEX) | Shortstop | ||||
| Izzy Alcántara (DOM) | Outfielder | ||||
| Mendy López (DOM) | Outfielder | ||||
| Robert Pérez (VEN) | Outfielder | ||||
| David Ortiz (DOM) | Designated hitter | ||||
| José Jiménez (DOM) | Right-handed pitcher | ||||
| Dámaso Marte (DOM) | Left-handed pitcher | ||||
| Francis Beltrán (DOM) | Relief pitcher | ||||
| Awards | |||||
| Francis Beltrán (DOM) | Most Valuable Player | ||||
| Manny Acta (DOM) | Manager | ||||