The 2004 Iowa State Cyclones football team represented Iowa State University in the 2004 NCAA Division I-A football season. They played their home games at Jack Trice Stadium in Ames, Iowa. They participated as members of the Big 12 Conference in the North Division. They were coached by head coach Dan McCarney and defeated Miami (OH) in the Independence Bowl 17–13.

Schedule

Date	Time	Opponent	Site	TV	Result	Attendance
September 3	1:00 p.m.	Northern Iowa*	Jack Trice Stadium Ames, IA		W 23–0	42,865
September 11	11:00 a.m.	at No. 16 Iowa*	Kinnick Stadium Iowa City, IA (Battle for the Cy-Hawk Trophy)	ESPN+	L 10–17	70,397
September 18	11:30 a.m.	Northern Illinois*	Jack Trice Stadium Ames, IA	FSN	W 48–41	39,902
October 2	1:00 p.m.	at No. 25 Oklahoma State	Boone Pickens Stadium Stillwater, OK		L 7–36	47,554
October 9	6:00 p.m.	Texas A&M	Jack Trice Stadium Ames, IA	PPV	L 3–34	44,307
October 16	12:30 p.m.	at Colorado	Folsom Field Boulder, CO	FSN	L 14–19	44,285
October 23	2:00 p.m.	at Baylor	Floyd Casey Stadium Waco, TX		W 26–25	25,249
October 30	1:00 p.m.	Kansas	Jack Trice Stadium Ames, IA		W 13–7	36,384
November 6	1:00 p.m.	Nebraska	Jack Trice Stadium Ames, IA		W 34–27	45,022
November 20	11:00 a.m.	at Kansas State	KSU Stadium Manhattan, KS (rivalry)	FSN	W 37–23	44,829
November 27	Noon	Missouri	Jack Trice Stadium Ames, IA (Battle for the Telephone Trophy)	ABC	L 14–17 OT	40,626
December 28	5:30 p.m.	vs. Miami (OH)*	Independence Stadium Shreveport, LA (Independence Bowl)	ESPN	W 17–13	43,000
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time

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