The 2005 Iowa State Cyclones football team represented Iowa State University during the 2005 NCAA Division I-A football season. They played their home games at Jack Trice Stadium in Ames, Iowa. They participated as members of the Big 12 Conference in the North Division. The team was coached by head coach Dan McCarney and lost 24–27 to Texas Christian in the Houston Bowl.

Schedule

Date	Time	Opponent	Rank	Site	TV	Result	Attendance	Source
September 3	6:00 p.m.	Illinois State*		Jack Trice Stadium Ames, IA		W 32–21	44,058	[1]
September 10	2:30 p.m.	No. 8 Iowa*		Jack Trice Stadium Ames, IA (Battle for the Cy-Hawk Trophy)	ABC	W 23–3	54,290
September 23	7:00 p.m.	at Army*	No. 22	Michie Stadium West Point, NY	ESPN2	W 28–21	25,007
October 1	2:30 p.m.	at Nebraska	No. 23	Memorial Stadium Lincoln, NE	ABC	L 20–27 2OT	77,743
October 8	1:00 p.m.	Baylor		Jack Trice Stadium Ames, IA		L 13–23	45,992
October 15	1:00 p.m.	at Missouri		Faurot Field Columbia, MO (Battle for the Telephone Trophy)		L 24–27 OT	55,016
October 22	1:00 p.m.	Oklahoma State		Jack Trice Stadium Ames, IA		W 37–10	43,964
October 29	2:30 p.m.	at Texas A&M		Kyle Field College Station, TX	ABC	W 42–14	86,172
November 5	1:00 p.m.	Kansas State		Jack Trice Stadium Ames, IA (rivalry)		W 45–17	42,686
November 12	6:00 p.m.	No. 22 Colorado		Jack Trice Stadium Ames, IA	FSN	W 30–16	49,242
November 26	11:30 a.m.	at Kansas		Memorial Stadium Lawrence, KS	FSN	L 21–24 OT	42,826
December 31	1:30 p.m.	vs. No. 14 TCU*		Reliant Stadium Houston, TX (Houston Bowl)	ESPN	L 21–24	37,286
*Non-conference game Homecoming Rankings from Coaches' Poll released prior to the game All times are in Central time

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Rankings