The 2005 UAB Blazers football team represented the University of Alabama at Birmingham (UAB) in the 2005 NCAA Division I-A football season and was the 15th team fielded by the school. The Blazers' head coach was Watson Brown, who served his 11th season in the positions. They played their home games at Legion Field in Birmingham, Alabama, and competed as a member of Conference USA. The Blazers finished their tenth season at the I-A level, and seventh affiliated with a conference with a record of 5–6 (3–5 C-USA).

Schedule

Date	Time	Opponent	Site	TV	Result	Attendance
September 3	11:30 a.m.	at No. 3 Tennessee*	Neyland Stadium Knoxville, TN	JP Sports	L 10–17	107,529
September 10	7:00 p.m.	at Troy*	Movie Gallery Stadium Troy, AL		W 27–7	22,299
September 17	6:00 p.m.	Jacksonville State*	Legion Field Birmingham, AL		W 35–28	23,109
October 1	6:00 p.m.	Rice	Legion Field Birmingham, AL		W 45–26	10,580
October 8	6:00 p.m.	SMU	Legion Field Birmingham, AL		L 27–28	23,255
October 15	4:00 p.m.	at Marshall	Joan C. Edwards Stadium Huntington, WV		L 19–20	27,182
October 21	7:00 p.m.	Southern Miss	Legion Field Birmingham, AL	ESPN	L 28–37	31,363
November 1	6:30 p.m.	at Memphis	Liberty Bowl Memorial Stadium Memphis, TN (Battle for the Bones)	ESPN2	W 37–20	47,669
November 12	3:00 p.m.	UCF	Legion Field Birmingham, AL	CSTV	L 21–27	12,199
November 19	5:05 p.m.	at No. 24 UTEP	Sun Bowl Stadium El Paso, TX		W 35–23	47,967
November 26	11:00 a.m.	at East Carolina	Dowdy–Ficklen Stadium Greenville, NC		L 23–31	26,990
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time

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