The 2006 Middle Tennessee Blue Raiders football team represented Middle Tennessee State University as member of the Sun Belt Conference during the 2006 NCAA Division I FBS football season. Led by first-year head coach Rick Stockstill, the Blue Raiders compiled an overall record of 7–6 with a mark of 6–1 in conference play, sharing the Sun Belt title with Troy. Middle Tennessee was invited to the Motor City Bowl, the program's first bowl game at the NCAA Division I Football Bowl Subdivision (FBS) level, where they lost to Central Michigan. The team played home games at Johnny "Red" Floyd Stadium in Murfreesboro, Tennessee.

Schedule

Date	Time	Opponent	Site	TV	Result	Attendance
August 31	6:00 p.m.	Florida International	Johnny "Red" Floyd Stadium Murfreesboro, TN	ESPN+	W 7–6	20,058
September 9	5:00 p.m.	at Maryland*	Byrd Stadium College Park, MD		L 10–24	47,704
September 14	6:00 p.m.	Tennessee Tech*	Johnny "Red" Floyd Stadium Murfreesboro, TN	ESPNU	W 44–0	20,806
September 23	6:00 p.m.	at No. 17 Oklahoma*	Gaylord Family Oklahoma Memorial Stadium Norman, OK		L 0–59	84,326
September 30	6:00 p.m.	at North Texas	Fouts Field Denton, TX	ESPN+	W 35–0	16,986
October 6	7:00 p.m	No. 8 Louisville*	LP Field Nashville, TN	ESPN2	L 17–44	32,797
October 21	6:00 p.m.	at Louisiana–Monroe	Malone Stadium Monroe, LA		W 35–21	11,717
October 28	4:00 p.m.	at Louisiana–Lafayette	Cajun Field Lafayette, LA		W 34–20	22,093
November 4	2:30 p.m.	Florida Atlantic	Johnny "Red" Floyd Stadium Murfreesboro, TN	CSS	W 35–14	18,712
November 11	4:00 p.m.	at Arkansas State	Indian Stadium Jonesboro, AR		W 38–10	10,176
November 18	11:30 a.m.	at South Carolina*	Williams–Brice Stadium Columbia, SC	PPV	L 7–52	70,442
November 25	2:30 p.m.	Troy	Johnny "Red" Floyd Stadium Murfreesboro, TN (Battle for the Palladium)	CSS	L 20–21	17,812
December 26	6:30 p.m.	vs. Central Michigan*	Ford Field Detroit, MI (Motor City Bowl)	ESPN	L 14–31	54,113
*Non-conference game Homecoming Rankings from AP Poll released prior to the game All times are in Central time

Starting lineup

Offense

Defense

Special teams

_{* Note: r before the class year means that the player has used a redshirt year.}

Game summaries

FIU

Maryland

Tennessee Tech

Oklahoma

North Texas

Louisville

Louisiana–Monroe

Louisiana–Lafayette

Florida Atlantic

Arkansas State

South Carolina

Troy

Motor City Bowl