Bracket
| Semi-Finals | Final | ||||||||||||
| 1 |  Enyimba
| 0 | 0 | 0 | |||||||||
| 4 |  Al Ahly
| 0 | 1 | 1 | |||||||||
| Al Ahly
| 2 | 2 | 4 | ||||||||||
 Coton Sport FC
| 0 | 2 | 2 | ||||||||||
| 3 |  Dynamos
| 0 | 0 | 0 | |||||||||
| 2 | Coton Sport FC
| 1 | 4 | 5 | |||||||||
The knockout stage of the 2008 CAF Champions League was played from 5 October to 16 November 2008.[1]
| Semi-Finals | Final | ||||||||||||
| 1 | Enyimba
| 0 | 0 | 0 | |||||||||
| 4 | Al Ahly
| 0 | 1 | 1 | |||||||||
| Al Ahly
| 2 | 2 | 4 | ||||||||||
| Coton Sport FC
| 0 | 2 | 2 | ||||||||||
| 3 | Dynamos
| 0 | 0 | 0 | |||||||||
| 2 | Coton Sport FC
| 1 | 4 | 5 | |||||||||
The first legs were played on 5 October and the second legs on 17–19 October.
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Enyimba
|
0–1 | Al Ahly
|
0–0 | 0–1 |
| Dynamos
|
0–5 | Coton Sport FC
|
0–1 | 0–4 |
| Enyimba FC | 0–0 | Al Ahly |
|---|---|---|
| Report |
| Al Ahly | 1–0 | Enyimba FC |
|---|---|---|
Flávio 26' |
| Dynamos | 0–1 | Coton Sport FC |
|---|---|---|
| Report | Kamilou 32' |
| Coton Sport FC | 4–0 | Dynamos |
|---|---|---|
| Koua 1' Zoua 52'Kamilou 65'Ousmaïla Baba 76' |
Report |
|
Main article: 2008 CAF Champions League Final |
| Team 1 | Agg. | Team 2 | 1st leg | 2nd leg |
|---|---|---|---|---|
| Al Ahly
|
4–2 | Coton Sport FC
|
2–0 | 2–2 |
| Al Ahly | 2–0 | Coton Sport FC |
|---|---|---|
| Gomaa 4' Flávio 15' |
Report |
| Coton Sport FC | 2–2 | Al Ahly |
|---|---|---|
| Lassina Abdoul Karim 45' Ousmaïla Baba 63' |
Report | Ahmed Hassan 38' Shady 89' |