The 2010 Drake Bulldogs football team represented Drake University as a member of the Pioneer Football League (PFL) during the 2010 NCAA Division I FCS football season. Led by third-year head coach Chris Creighton, the Bulldogs compiled an overall record of 7–4 with a mark of 6–2 in conference play, placing third in the PFL. In May 2011, Drake played in the 2011 Kilimanjaro Bowl, the first college football game held on the continent of Africa. The team played its home games at Drake Stadium in Des Moines, Iowa.

Schedule

Date	Time	Opponent	Site	Result	Attendance	Source
September 4	6:00 p.m.	No. 19 Lehigh*	Drake Stadium Des Moines, IA	L 14–28	3,628	[1]
September 11	7:00 p.m.	at Missouri S&T*	Allgood–Bailey Stadium Rolla, MO	W 28–14	3,200
September 18	2:00 p.m.	at No. 6 Montana State*	Bobcat Stadium Bozeman, MT	L 21–48	13,777
September 25	1:00 p.m.	at Valparaiso	Brown Field Valparaiso, IN	W 21–19	3,116
October 2	1:00 p.m.	Marist	Drake Stadium Des Moines, IA	W 42-0	3,421
October 9	11:00 a.m.	at No. 18 Jacksonville	D. B. Milne Field Jacksonville, FL	L 34–39	2,843
October 16	12:00 p.m.	at Campbell	Barker–Lane Stadium Buies Creek, NC	W 14–12	2,474
October 23	1:00 p.m.	Davidson	Drake Stadium Des Moines, IA	W 42–10	2,186
October 30	1:00 p.m.	San Diego	Drake Stadium Des Moines, IA	W 38–17	1,997
November 6	12:00 p.m.	at Dayton	Welcome Stadium Dayton, OH (rivalry)	L 25–31	1,723
November 13	1:00 p.m.	Butler	Drake Stadium Des Moines, IA (rivalry)	W 10–7	1,598
May 21, 2011	2:30 p.m.	vs. CONADEIP*	Sheikh Amri Abeid Memorial Stadium Arusha, Tanzania (Kilimanjaro Bowl)	W 17–7	11,781
*Non-conference game Homecoming Rankings from The Sports Network Poll released prior to the game All times are in Central time