In the fourth round action Jo Wilfried Tsonga cruised over Juan Carlos Ferrero 6−2, 6−2 to set up a clash against Rafael Nadal who downed compatriot David Ferrer 7–6(5), 6–4.[8]Andy Roddick also made through the quarterfinals recovering from a 1−4 (0−40) scoreline in the first set to defeat Benjamin Becker 7−6(4), 6−3[9] and is scheduled to face Nicolás Almagro who grinded out a 3 set win over Thomaz Bellucci. The other Quarterfinal showdown is between Mikhail Youzhny who defeated Mardy Fish taking on Robin Söderling who won over Fernando González. Fernando Verdasco also made through with a 6-4 7–6(3) coming back from a break down in the second set over Marin Čilić. He is now scheduled to face Tomáš Berdych who upset Roger Federer 6–4, 6-7(3), 7-6(6) saving a match point en route to the victory.[10] In the first of the battle for the semi-finals Andy Roddick made quick work of Nicolás Almagro with a 6−3, 6−3 in just 80 minutes breaking the Spaniards serve 3 times and saving the only two break points he faced in the second round.[11] The American defeated 4−6, 6−3, 6−3 Rafael Nadal who also had had an easy victory over Frenchman Jo-Wilfried Tsonga breaking the Tsonga serve 4 times and saving all 8 break points he faced to earn a 6−3, 6−2 victory.[12] Following Nadal and Roddick in the semifinals was Tomáš Berdych who survived against Fernando Verdasco two days after defeating Roger Federer 4−6, 7−6(5), 6−4 with both players saving 7 of 9 break points.[13] Berdych defeated Swede Robin Söderling who had cruised over Mikhail Youzhny with a 6−1, 6−4.[14] In the first semifinal saw Andy Roddick taking on Rafael Nadal with leading the head-to-head 5−2 with a 3 match winning streak and 7 straight sets. However the American was able to upset Spaniard 4−6, 6−3, 6−3 with Roddick changing strategies in the middle of the second set and being more agrresive and breaking the Spaniard 3 times with himself getting broken once. Nadal reacted on Roddick' change of tactics he said "I started the match playing pretty well in the beginning. Later in the second set Andy was serving well; I didn't have a lot of chances on the return. He started to play more aggressive in the game where he broke me. It was a change, and it was surprise for me.".[15] In the second semifinal saw Tomáš Berdych continue his marvelous run and upsetting Robin Söderling with a 6−2, 6−2 crushing victory over the Swede breaking the Swede 4 times and saving the only break point he faced.[16]
In the finals it was Roddick's 10th Masters final and the 2nd for Berdych. In their head-to-head Roddick is above Berdych 5−2, and Roddick has won their 3 previous encounters including 2 this year.[17] In the match, it was completely even as both players did not face a single break point up until 5-5, where Berdych save a break point but double faulted and went long to give Roddick the break, and serve out the first set at love. In the second set Roddick got to an early start as he broke for a 2−0 lead and even had match points at 5−3 but BErdych fend it off, but Roddick serve it out to win the set 6−4 and the match. Asked what most pleased him about the title run, Roddick said: "I won in different ways. I changed it up against Rafa and today I was smart with chipping and mixing paces, which kept him guessing. I held onto my serve well throughout and played a pretty smart tournament.". "He was just too strong today", Berdych said. "He's not just serving the big bombs. His variations of the serve are a really big improvement. … I was really looking for maybe to get one chance, but he held pretty well. I didn’t get any chance during whole match.".[18][19][20]
It was Roddick's second title of the year and 29th of his career. It was his 5th Masters 1000 title. It was his 2nd win at Miami, also winning in 2004.
In the first day of the Quarterfinals Venus Williams recorded her 5th straight victory over Agnieszka Radwańska convincingly 6−3, 6−1 breaking the Radwańska serve five times, with her serve getting broken once.[23] Venus was followed by Marion Bartoli who edged out one of three Belgians in the quarterfinals Yanina Wickmayer 6−4, 7−5 the match featured 12 breaks of serve 7−5 to Bartoli as both players struggled on serve. The meeting between Bartoli and Venus is their first match that is not a final. Bartoli and Venus was joined in by the Belgians Kim Clijsters and Justine Henin in the Semifinals. Kim Clijsters had an easier victory as she dispatched Australian Samantha Stosur 6–3, 7–5 in just over 70 minutes,[24] while Justine Henin needed twice as more time to grind over world no. 2 Caroline Wozniacki with a 6–7(5), 6–3, 6–4 victory.[25] In the Semifinals Venus Williams made a quick work of Marion Bartoli winning 6−4, 6−3. Bartoli made four double faults in the sixth and stated that "It was all terrible. The more I was thinking, okay, just put your first serve in, the worse it was getting. I think it's also the part that she's so inside the baseline. I would just put the first serve in, and she would just get over it and kill me on the return of serve. That really put a lot of pressure on [me]." she then added "I think that's also what sets her apart from the other players. Like Serena, when you get her in front of you, it's not like an average player returning your serve. If you're not serving perfectly, she gonna hit a great return and [you will] be on defense." This is Venus' 15th straight win.[26] In the 2nd semifinals in a Belgian encounter saw Kim Clijsters outlasted compatriot Justine Henin 6−2, 6−7(3), 7−6(6) to even their head-to-head 12−12.[27]
In the finals the head-to-head was 6−5 in favor of the American. However it was the Belgian Kim Clijsters who dominated her most fancied opponent American Venus Williams 6−2, 6−1, thus breaking the Americans 15 match winning streak and the Belgian returning to the top 10. "It took a lot of hard work to get back into shape and I have a few people to thank, including my fitness coach and husband", Clijsters said during the on-court ceremony. "It feels really good to be back here, having won the title in 2005. It's always nice to come back to a place you have done well before, and to such a beautiful stadium." The Belgian added. The older Williams stated that "Sometimes when you hit a few bad shots it's not as easy to reel it in, and things start to go a little bit quicker. Every now and then it happens to the best of us. I think this happened to Kim in Australia, so I think she knows what it's like. Wasn't the best day, but that's, I guess, sport sometimes." and added "Obviously against a player like Kim, if you make too many errors, the match can go quickly. I mean, I think she hit eight winners, so it wasn't she played extremely solid; it's not like I was blown off the court. Unfortunately I was my own worst enemy today.". Clijsters then said "What has changed for me now is whatever I do at the courts, it's almost like my time off", Clijsters said. "I get to come here, work out and play my matches. It's like Mommy time. When I’m done, I’m really focused on my family life, and I like the balance.".[28][29]
In the quarterfinals 4th seeds Rennae Stubbs and Lisa Raymond advance with a comfortable win over Alisa Kleybanova and Francesca Schiavone, while Stubbs former partner Samantha Stosur also advance with Nadia Petrova with a win over Julie Coin and Vania King. In the semifinals Nadia Petrova and Samantha Stosur defeated the team of Chan Yung-jan and Zheng Jie in a 6–1, 7–5 final score, and the team of Gisela Dulko and Flavia Pennetta also advanced to the final defeating Lisa Raymond and Rennae Stubbs double 6–4. In the semifinals saw Nadia Petrova and Samantha Stosur advancing to the finals in a convincing fashion with a 6–1, 7–5 victory over Chan Yung-jan and Zheng Jie. In the second semifinals saw Gisela Dulko and Flavia Pennetta upsetting 4th seeds Lisa Raymond and Rennae Stubbs in a straight set 6–4, 6–4 victory. In the final it was the pair Gisela Dulko and Flavia Pennetta who produce another upset as they defeated 3rd seeds Nadia Petrova and Samantha Stosur, thus defeating 3 of the top 4 seeds after upsetting 2nd seeds Nuria Llagostera Vives and María José Martínez Sánchez in the second round and 3rd seeds Lisa Raymond and Rennae Stubbs in the semifinals. This is Dulko and Pennetta's first Mandatory level doubles title as a team and as individuals.[31]
A record total of 312,386 visited the Crandon Park Tennis Center including a sellout crowd of 14,119 for the men's final on Sunday, April 4. The men's final sold out on March 8, marking the quickest sellout for a men's final in tournament history.[32]
Andy Roddick
Kim Clijsters
Lukáš Dlouhý / 
Leander Paes
Gisela Dulko / 
Flavia Pennetta
