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((Use mdy dates|date=November 2013))
((More citations needed|date=July 2023))
((Infobox baseball team season
| name = Cleveland Indians
| imgwidth = 
| caption = 
| season = 2021
| misc = 
| image = Cleveland Indians primary logo.svg
| league = American League
| division = [[American League Central|Central]]
| ballpark = [[Progressive Field]]
| city = [[Cleveland, Ohio]]
| record = ((winpct|80|82|record=y))
| divisional_place = 2nd
| owners = [[Larry Dolan]]
| presbo = [[Chris Antonetti]]
| general_managers = [[Mike Chernoff (baseball)|Mike Chernoff]]
| managers = [[Terry Francona]]
| television = [[Bally Sports Great Lakes]]((·)) [[WKYC]]<br><small>([[Matt Underwood]], [[Rick Manning]])</small>
| radio = [[WTAM]]((·)) [[WMMS]]<br>[[Cleveland Indians Radio Network]]<br><small>([[Tom Hamilton (broadcaster)|Tom Hamilton]], [[Jim Rosenhaus]], [[Rick Manning]])</small>
| next_season = 2022 Cleveland Guardians season
))
The '''2021 Cleveland Indians season''' was the 121st season for the franchise. It was the ninth season under the leadership of manager [[Terry Francona]] and sixth under general manager [[Mike Chernoff (baseball)|Mike Chernoff]]. The Indians played their home games at [[Progressive Field]] in [[Cleveland, Ohio]].

This was the team's final season under the name Indians. Following the season, the team became known as the Cleveland Guardians after [[Cleveland Indians name and logo controversy|decades of controversy]] surrounding the "Indians" name.

The Indians made MLB history by becoming the first team to be no-hit three times in a single season.<ref>((Cite web |title=Plesac, Indians no-hit for 3rd time in 2021 |url=https://www.mlb.com/news/indians-no-hit-for-3rd-time-in-2021-by-brewers |access-date=2023-06-29 |website=MLB.com |language=en))</ref> Those three no-hitters came off of [[Carlos Rodón]] of the [[Chicago White Sox]] on April 14,<ref>((Cite web |title=Cleveland 'overwhelmed' by Rodón in no-no |url=https://www.mlb.com/news/cleveland-indians-no-hit-by-white-sox |access-date=2023-06-29 |website=MLB.com |language=en))</ref> [[Wade Miley]] of the [[Cincinnati Reds]] on May 7,<ref>((Cite web |title=Miley pitches MLB's 2nd no-no THIS WEEK! |url=https://www.mlb.com/news/wade-miley-throws-no-hitter-vs-indians |access-date=2023-06-29 |website=MLB.com |language=en))</ref> and [[Corbin Burnes]] and [[Josh Hader]] of the [[Milwaukee Brewers]] on September 11. By coincidence, [[Zach Plesac]] was their starting pitcher in all three no-hitters. In addition, they were held hitless in a seven-inning doubleheader game against the Tampa Bay Rays.

==Season standings==

===American League Central===
((2021 AL Central standings|highlight=Cleveland Indians))

===American League Wild Card===
((2021 AL Wild Card standings|highlight=Cleveland Indians))

===Record against opponents===

((2021 AL Record vs. opponents|team=CLE))

==Game log==
((Game log start|style=((Baseball primary style|Cleveland Indians));|title= 2021 Game Log: 80–82 (Home: 40–41; Away: 40–41)))
((Game log section start|hide=y|style=((Baseball secondary style|Cleveland Indians));|title=April: 12–12 (Home: 7–6; Away: 5–6)| #| Date| Opponent| Score| Win| Loss| Save| Attendance| Record| Streak))Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed -->
|- style="background:#fbb
| 1 || April 1 || @ [[2021 Detroit Tigers season|Tigers]] || 2–3 || [[Matthew Boyd (baseball)|Boyd]] (1–0) || '''[[Shane Bieber|Bieber]]''' (0–1) || [[Gregory Soto|Soto]] (1) || 8,000 || 0–1 || L1
|- style="background:#fbb
| 2 || April 3 || @ [[2021 Detroit Tigers season|Tigers]] || 2–5 || [[Julio Teherán|Teherán]] (1–0) || '''[[Zach Plesac|Plesac]]''' (0–1) || [[Bryan Garcia (baseball)|Garcia]] (1) || 8,000 || 0–2 || L2
|- style="background:#bfb
| 3 || April 4 || @ [[2021 Detroit Tigers season|Tigers]] || 9–3 || '''[[Aaron Civale|Civale]]''' (1–0) || [[Daniel Norris (baseball)|Norris]] (0–1) ||  || 8,000 || 1–2 || W1
|- style="background:#fbb
| 4 || April 5 || [[2021 Kansas City Royals season|Royals]] || 0–3 || [[Danny Duffy|Duffy]] (1–0) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (0–1) || [[Jesse Hahn|Hahn]] (1) || 8,914 || 1–3 || L1
|- style="background:#bfb
| 5 || April 7 || [[2021 Kansas City Royals season|Royals]] || 4–2 || '''[[Emmanuel Clase|Clase]]''' (1–0) || [[Greg Holland|Holland]] (0–1) || '''[[Nick Wittgren|Wittgren]]''' (1) || 5,908 || 2–3 || W1
|- style="background:#bfb
| 6 || April 9 || [[2021 Detroit Tigers season|Tigers]] || 4–1 || '''[[Zach Plesac|Plesac]]''' (1–1) || [[Derek Holland|Holland]] (0–1) || '''[[Emmanuel Clase|Clase]]''' (1) || 7,775 || 3–3 || W2
|- style="background:#bfb
| 7 || April 10 || [[2021 Detroit Tigers season|Tigers]] || 11–3 || '''[[Aaron Civale|Civale]]''' (2–0) || [[Tarik Skubal|Skubal]] (0–1) ||  || 7,570 || 4–3 || W3
|- style="background:#bfb
| 8 || April 11 || [[2021 Detroit Tigers season|Tigers]] || 5–2 || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–1) || [[Jose Urena|Urena]] (0–2) || '''[[Emmanuel Clase|Clase]]''' (2) || 6,859 || 5–3 || W4
|- style="background:#fbb
| 9 || April 12 || @ [[2021 Chicago White Sox season|White Sox]] || 3–4 || [[Codi Heuer|Heuer]] (1–0) || '''[[Emmanuel Clase|Clase]]''' (1–1) ||  || 7,393 || 5–4 || L1
|- style="background:#bfb
| 10 || April 13 || @ [[2021 Chicago White Sox season|White Sox]] || 2–0 ((small|(10))) || '''[[Shane Bieber|Bieber]]''' (1–1) || [[Garrett Crochet|Crochet]] (0–2) || '''[[James Karinchak|Karinchak]]''' (1) || 7,102 || 6–4 || W1
|- style="background:#fbb;"
| 11 || April 14 || @ [[2021 Chicago White Sox season|White Sox]] || 0–8 || [[Carlos Rodón|Rodón]] (2–0) || '''[[Zach Plesac|Plesac]]''' (1–2) ||  || 7,148 || 6–5 || L1
|- style="background: #bfb
| 12 || April 15 || @ [[2021 Chicago White Sox season|White Sox]] || 4–2 || '''[[Aaron Civale|Civale]]''' (3–0) || [[Lance Lynn|Lynn]] (1–1) || '''[[Emmanuel Clase|Clase]]''' (3) || 7,049 || 7–5 || W1
|- style="background:#fbb
| 13 || April 16 || @ [[2021 Cincinnati Reds season|Reds]] || 3–10 || [[Jeff Hoffman|Hoffman]] (2–1) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–2) ||  || 12,497 || 7–6 || L1
|- style="background:#fbb
| 14 || April 17 || @ [[2021 Cincinnati Reds season|Reds]] || 2–3 ((small|(10))) || [[Sean Doolittle|Doolittle]] (2–0) || '''[[Oliver Pérez|Pérez]]''' (0–1) ||  || 12,598 || 7–7 || L2
|- style="background:#bfb 
| 15 || April 18 || @ [[2021 Cincinnati Reds season|Reds]] || 6–3 || '''[[Shane Bieber|Bieber]]''' (2–1) || [[Wade Miley|Miley]] (2–1) || '''[[Emmanuel Clase|Clase]]''' (4) || 12,551 || 8–7 || W1
|- style="background:#fbb
| 16 || April 20 || [[2021 Chicago White Sox season|White Sox]] || 5–8 || [[Carlos Rodón|Rodón]] (3–0) || '''[[Zach Plesac|Plesac]]''' (1–3) ||  || 4,176 || 8–8 || L1
|- style="background: #bbb
| — || April 21 || [[2021 Chicago White Sox season|White Sox]] || colspan=7 | ''Postponed (rain) make-up date May 31
|- style="background:#fbb
| 17 || April 22 || [[2021 New York Yankees season|Yankees]] || 3–6 || [[Domingo Germán|Germán]] (1–2) || '''[[Nick Wittgren|Wittgren]]''' (0–1) || [[Aroldis Chapman|Chapman]] (3) || 6,380 || 8–9 || L2
|- style="background:#fbb;"
| 18 || April 23 || [[2021 New York Yankees season|Yankees]] || 3–5 || [[Lucas Luetge|Luetge]] (1–0) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–3) || [[Aroldis Chapman|Chapman]] (4) || 8,662 || 8–10 || L3
|- style="background:#fbb
| 19 || April 24 || [[2021 New York Yankees season|Yankees]] || 1–2 || [[Gerrit Cole|Cole]] (3–1) || '''[[Shane Bieber|Bieber]]''' (2–2) || [[Jonathan Loáisiga|Loáisiga]] (1) || 8,817 || 8–11 || L4
|- style="background:#bfb
| 20 || April 25 || [[2021 New York Yankees season|Yankees]] || 7–3 || '''[[Sam Hentges|Hentges]]''' (1–0) || [[Jameson Taillon|Taillon]] (0–2) ||  || 8,766 || 9–11 || W1
|- style="background:#bfb
| 21 || April 26 || [[2021 Minnesota Twins season|Twins]] || 5–3 ((small|(10))) || '''[[Emmanuel Clase|Clase]]''' (2–1) || [[Álex Colomé|Colomé]] (1–3) ||  || 4,555 || 10–11 || W2
|- style="background:#bfb
| 22 || April 27 || [[2021 Minnesota Twins season|Twins]] || 7–4 || '''[[Aaron Civale|Civale]]''' (4–0) || [[Kenta Maeda|Maeda]] (1–2) || '''[[James Karinchak|Karinchak]]''' (2) || 6,303 || 11–11 || W3
|- style="background:#fbb 
| 23 || April 28 || [[2021 Minnesota Twins season|Twins]] || 2–10 || [[J. A. Happ|Happ]] (2–0) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–4) ||  || 5,903 || 11–12 || L1
|- style="background:#bfb 
| 24 || April 30 || @ [[2021 Chicago White Sox season|White Sox]] || 5–3 || '''[[Shane Bieber|Bieber]]''' (3–2) || [[Dallas Keuchel|Keuchel]] (1–1) || '''[[Emmanuel Clase|Clase]]''' (5) || 9,405 || 12–12 || W1
|-
((Game log section end))
((Game log section start|hide=y|style=((Baseball secondary style|Cleveland Indians));|title=May: 17–12 (Home: 6–6; Away: 11–6)| #| Date| Opponent| Score| Win| Loss| Save| Attendance| Record| Streak))Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed -->
|- style="background:#fbb 
| 25|| May 1 || @ [[2021 Chicago White Sox season|White Sox]] || 3–7 || [[Lance Lynn|Lynn]] (2–1) || '''[[Triston McKenzie|McKenzie]]''' (0–1) ||  || 9,451 || 12–13 || L1
|- style="background:#bfb
| 26 || May 2 || @ [[2021 Chicago White Sox season|White Sox]] || 5–0 || '''[[Zach Plesac|Plesac]]''' (2–3) || [[Lucas Giolito|Giolito]] (1–3) ||  || 9,471 || 13–13 || W1
|- style="background:#bfb 
| 27 || May 3 || @ [[2021 Kansas City Royals season|Royals]] || 8–6 || '''[[Bryan Shaw (baseball)|Shaw]]''' (1–0) || [[Jakob Junis|Junis]] (1–2) || '''[[Emmanuel Clase|Clase]]''' (6) || 6,919 || 14–13 || W2
|- style="background:#bfb
| 28 || May 4 || @ [[2021 Kansas City Royals season|Royals]] || 7–3 || '''[[Nick Wittgren|Wittgren]]''' (1–1) || [[Josh Staumont|Staumont]] (0–1) ||  || 5,997 || 15–13 || W3
|- style="background:#bfb 
| 29 || May 5 || @ [[2021 Kansas City Royals season|Royals]] || 5–4 || '''[[Nick Wittgren|Wittgren]]''' (2–1) || [[Wade Davis (baseball)|Davis]] (0–1) || '''[[James Karinchak|Karinchak]]''' (3) || 9,640 || 16–13 || W4
|- style="background:#bfb 
| 30 || May 6 || @ [[2021 Kansas City Royals season|Royals]] || 4–0 || '''[[Triston McKenzie|McKenzie]]''' (1–1) || [[Danny Duffy|Duffy]] (4–2) ||  || 9,259 || 17–13 || W5
|- style="background:#fbb 
| 31 || May 7 || [[2021 Cincinnati Reds season|Reds]] || 0–3 || [[Wade Miley|Miley]] (4–2) || '''[[Emmanuel Clase|Clase]]''' (2–2) ||  || 7,803 || 17–14 || L1
|- style="background:#bfb
| 32 || May 8 || [[2021 Cincinnati Reds season|Reds]] || 9–2 || '''[[Aaron Civale|Civale]]''' (5–0) || [[Luis Castillo (pitcher, born 1992)|Castillo]] (1–4) ||  || 9,968 || 18–14 || W1
|- style="background:#bbb
| — || May 9 || [[2021 Cincinnati Reds season|Reds]] || colspan=7 | ''Postponed (rain) make-up date August 9
|- style="background:#bfb
| 33 || May 11 || [[2021 Chicago Cubs season|Cubs]] || 3–2 || '''[[Shane Bieber|Bieber]]''' (4–2) || [[Adbert Alzolay|Alzolay]] (1–3) || '''[[Emmanuel Clase|Clase]]''' (7) || 8,024 || 19–14 || W2
|- style="background:#bfb 
| 34 || May 12 || [[2021 Chicago Cubs season|Cubs]] || 2–1 ((small|(10))) || '''[[James Karinchak|Karinchak]]''' (1–0) || [[Keegan Thompson|Thompson]] (1–1) || — || 8,589 || 20–14 || W3
|- style="background:#bfb 
| 35 || May 13 || @ [[2021 Seattle Mariners season|Mariners]] || 4–2 || '''[[Zach Plesac|Plesac]]''' (3–3) || [[Logan Gilbert|Gilbert]] (0–1) || '''[[Bryan Shaw (baseball)|Shaw]]''' (1) || 9,880 || 21–14 || W4
|- style="background:#fbb 
| 36 || May 14 || @ [[2021 Seattle Mariners season|Mariners]] || 3–7 || [[Chris Flexen|Flexen]] (4–1) || '''[[Aaron Civale|Civale]]''' (5–1) || [[Rafael Montero (baseball)|Montero]] (5) || 10,014 || 21–15 || L1
|- style="background:#fbb
| 37 || May 15 || @ [[2021 Seattle Mariners season|Mariners]] || 3–7 || [[Justus Sheffield|Sheffield]] (3–3) || '''[[Triston McKenzie|McKenzie]]''' (1–2) ||  || 10,311 || 21–16 || L2
|- style="background:#fbb
| 38 || May 16 || @ [[2021 Seattle Mariners season|Mariners]] || 2–3 || [[Paul Sewald|Sewald]] (1–0) || '''[[Shane Bieber|Bieber]]''' (4–3) || [[Kendall Graveman|Graveman]] (5) || 10,287 || 21–17 || L3
|- style="background:#fbb 
| 39 || May 17 || @ [[2021 Los Angeles Angels season|Angels]] || 4–7 || [[Tony Watson|Watson]] (2–1) || '''[[Sam Hentges|Hentges]]''' (1–1) || [[Raisel Iglesias|Iglesias]] (7) || 9,527 || 21–18 || L4
|- style="background:#bfb
| 40 || May 18 || @ [[2021 Los Angeles Angels season|Angels]] || 6–5 || '''[[Zach Plesac|Plesac]]''' (4–3) || [[Alex Claudio|Claudio]] (0–1) || '''[[James Karinchak|Karinchak]]''' (4) || 9,491 || 22–18 || W1
|- style="background:#bfb
| 41 || May 19 || @ [[2021 Los Angeles Angels season|Angels]] || 3–2 || '''[[Aaron Civale|Civale]]''' (6–1) || [[Tony Watson|Watson]] (2–2) || '''[[James Karinchak|Karinchak]]''' (5) || 10,378 || 23–18 || W2
|- style="background:#fbb 
| 42 || May 21 || [[2021 Minnesota Twins season|Twins]] || 0–10 || [[Randy Dobnak|Dobnak]] (1–3) || '''[[Triston McKenzie|McKenzie]]''' (1–3) || — || 11,675 || 23–19 || L1
|- style="background:#bfb 
| 43 || May 22 || [[2021 Minnesota Twins season|Twins]] || 5–3 ((small|(10))) || '''[[James Karinchak|Karinchak]]''' (2–0) || [[Álex Colomé|Colomé]] (2–4) || — || 11,505 || 24–19 || W1
|- style="background:#fbb 
| 44 || May 23 || [[2021 Minnesota Twins season|Twins]] || 5–8 ((small|(10))) || [[Hansel Robles|Robles]] (1–1) || '''[[James Karinchak|Karinchak]]''' (2–1) || [[Tyler Duffey|Duffey]] (1) || 9,805 || 24–20 || L1
|- style="background:#bfb
| 45 || May 24 || @ [[2021 Detroit Tigers season|Tigers]] || 6–5 || '''[[Jean Carlos Mejía|Mejía]]''' (1–0) || [[Bryan Garcia (baseball)|Garcia]] (0–1) || '''[[Emmanuel Clase|Clase]]''' (8) || 7,832 || 25–20 || W1
|- style="background:#bfb
| 46 || May 25 || @ [[2021 Detroit Tigers season|Tigers]] || 4–0 || '''[[Aaron Civale|Civale]]''' (7–1) || [[Tarik Skubal|Skubal]] (1–7) || '''[[James Karinchak|Karinchak]]''' (6) || 8,000 || 26–20 || W2
|- style="background:#fbb
| 47 || May 26 || @ [[2021 Detroit Tigers season|Tigers]] || 0–1 || [[Michael Fulmer|Fulmer]] (4–3) || '''[[Cal Quantrill|Quantrill]]''' (0–1) || [[Gregory Soto|Soto]] (5) || 7,525 || 26–21 || L1
|- style="background:#bfb 
| 48|| May 27 || @ [[2021 Detroit Tigers season|Tigers]] || 5–2 || '''[[Shane Bieber|Bieber]]''' (5–3) || [[Matthew Boyd (baseball)|Boyd]] (2–6) || — || 8,000 || 27–21 || W1
|- style="background:#fbb
| 49 || May 28 || [[2021 Toronto Blue Jays season|Blue Jays]] || 2–11 ((small|(7))) || [[Hyun-jin Ryu|Ryu]] (5–2) || '''[[Eli Morgan|Morgan]]''' (0–1) || — || 9,198 || 27–22 || L1
|- style="background:#bbb 
| — || May 29 || [[2021 Toronto Blue Jays season|Blue Jays]] || colspan=7 | ''Postponed (high winds) make-up date May 30
|- style="background:#fbb
| 50 || May 30 ((small|(G1))) || [[2021 Toronto Blue Jays season|Blue Jays]] || 1–4 ((small|(7))) || [[Ross Stripling|Stripling]] (1–3) || '''[[Aaron Civale|Civale]]''' (7–2) || [[Jordan Romano|Romano]] (3) || &mdash; || 27–23 || L2
|- style="background:#bfb 
| 51 || May 30 ((small|(G2))) || [[2021 Toronto Blue Jays season|Blue Jays]] || 6–5 ((small|(7))) || '''[[Emmanuel Clase|Clase]]''' (3–2) || [[Tyler Chatwood|Chatwood]] (0–2) || — || 11,690 || 28–23 || W1
|- style="background:#fbb
| 52 || May 31 ((small|(G1))) || [[2021 Chicago White Sox season|White Sox]] || 6–8 ((small|(8))) || [[Codi Heuer|Heuer]] (4–1) || '''[[James Karinchak|Karinchak]]''' (2–2) || [[Aaron Bummer|Bummer]] (1) || &mdash; || 28–24 || L1
|- style="background:#bfb
| 53 || May 31 ((small|(G2))) || [[2021 Chicago White Sox season|White Sox]] || 3–1 ((small|(7))) || '''[[Phil Maton|Maton]]''' (1–0) || [[Jimmy Lambert|Lambert]] (0–1) || '''[[Emmanuel Clase|Clase]]''' (9) || 10,726 || 29–24 || W1
|-
((Game log section end))
((Game log section start|hide=y|style=((Baseball secondary style|Cleveland Indians));|title=June: 13–11 (Home: 8–3; Away: 5–8)| #| Date| Opponent| Score| Win| Loss| Save| Attendance| Record| Streak))Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed -->
|- style="background:#bfb 
| 54 || June 1 || [[2021 Chicago White Sox season|White Sox]] || 6–5 || '''[[Shane Bieber|Bieber]]''' (6–3) || [[Dylan Cease|Cease]] (3–2) || '''[[James Karinchak|Karinchak]]''' (7) || 7,132 || 30–24 || W2
|- style="background:#bbb 
| — || June 2 || [[2021 Chicago White Sox season|White Sox]] || colspan=7 | ''Postponed (rain) make-up date September 23
|- style="background:#fbb
| 55 || June 4 || @ [[2021 Baltimore Orioles season|Orioles]] || 1–3 || [[Cole Sulser|Sulser]] (2–0) || '''[[Bryan Shaw (baseball)|Shaw]]''' (1–1) || [[Paul Fry (baseball)|Fry]]  (2) || 12,009 || 30–25 || L1
|- style="background:#bfb 
| 56 || June 5 || @ [[2021 Baltimore Orioles season|Orioles]] || 10–4 || '''[[Aaron Civale|Civale]]''' (8–2) || [[John Means (baseball)|Means]] (4–2) ||  || 9,969 || 31–25 || W1
|- style="background:#fbb
| 57 || June 6 || @ [[2021 Baltimore Orioles season|Orioles]] || 5–18 || [[Jorge López (baseball)|López]] (2–6) || '''[[Cal Quantrill|Quantrill]]''' (0–2) ||  || 9,423 || 31–26 || L1
|- style="background:#bfb
| 58 || June 8 || @ [[2021 St. Louis Cardinals season|Cardinals]] || 10–1 || '''[[Shane Bieber|Bieber]]''' (7–3) || [[Carlos Martínez (pitcher, born 1991)|Martínez]] (3–6) ||  || 16,178 || 32–26 || W1
|- style="background:#fbb 
| 59 || June 9 || @ [[2021 St. Louis Cardinals season|Cardinals]] || 2–8 || [[Adam Wainwright|Wainwright]] (4–5) || '''[[Jean Carlos Mejía|Mejía]]''' (0–1) ||  || 16,331 || 32–27 || L1
|- style="background:#bfb 
| 60 || June 11 || [[2021 Seattle Mariners season|Mariners]] || 7–0 || '''[[Aaron Civale|Civale]]''' (9–2) || [[Justin Dunn|Dunn]] (1–3) ||  || 22,970 || 33–27 || W1
|- style="background:#bfb 
| 61 || June 12 || [[2021 Seattle Mariners season|Mariners]] || 5–4 ((small|(10))) || '''[[James Karinchak|Karinchak]]''' (3–2) || [[Paul Sewald|Sewald]] (2–2) ||  || 20,116 || 34–27 || W2
|- style="background:#fbb
| 62 || June 13 || [[2021 Seattle Mariners season|Mariners]] || 2–6 || [[Logan Gilbert|Gilbert]] (2–2) || '''[[Shane Bieber|Bieber]]''' (7–4) ||  || 17,371 || 34–28 || L1
|- style="background:#bfb
| 63 || June 14 || [[2021 Baltimore Orioles season|Orioles]] || 4–3 || '''[[Nick Sandlin|Sandlin]]''' (1–0) || [[Dean Kremer|Kremer]] (3–6) || '''[[Emmanuel Clase|Clase]]''' (10) || 11,181 || 35–28 || W1
|- style="background:#bfb 
| 64 || June 15 || [[2021 Baltimore Orioles season|Orioles]] || 7–2 || '''[[James Karinchak|Karinchak]]''' (4–2) || [[Matt Harvey|Harvey]] (3–8) ||  || 12,025 || 36–28 || W2
|- style="background:#bfb
| 65 || June 16 || [[2021 Baltimore Orioles season|Orioles]] || 8–7 || '''[[Aaron Civale|Civale]]''' (10–2) || [[Keegan Akin|Akin]] (0–2) || '''[[Emmanuel Clase|Clase]]''' (11) || 12,825 || 37–28 || W3
|- style="background:#bfb 
| 66 || June 17 || [[2021 Baltimore Orioles season|Orioles]] || 10–3 || '''[[Trevor Stephan|Stephan]]''' (1–0) || [[Jorge López (baseball)|López]] (2–8) || — || 15,121 || 38–28 || W4
|- style="background:#fbb
| 67 || June 18 || @ [[2021 Pittsburgh Pirates season|Pirates]] || 10–11 || [[Chad Kuhl|Kuhl]] (1–4) || '''[[Jean Carlos Mejía|Mejía]]''' (1–2) || [[Richard Rodriguez|Rodriguez]] (8) || 16,965 || 38–29 || L1
|- style="background:#fbb 
| 68 || June 19 || @ [[2021 Pittsburgh Pirates season|Pirates]] || 3–6 || [[Chris Stratton|Stratton]] (2–0) || '''[[Bryan Shaw (baseball)|Shaw]]''' (1–2) || — || 16,830 || 38–30 || L2
|- style="background:#bfb
| 69 || June 20 || @ [[2021 Pittsburgh Pirates season|Pirates]] || 2–1 || '''[[Phil Maton|Maton]]''' (2–0) || [[J. T. Brubaker|Brubaker]] (4–6) || '''[[James Karinchak|Karinchak]]''' (8) || 16,582 || 39–30 || W1
|- style="background:#bfb
| 70 || June 21 || @ [[2021 Chicago Cubs season|Cubs]] || 4–0 || '''[[Bryan Shaw (baseball)|Shaw]]''' (2–2) || [[Adbert Alzolay|Alzolay]] (4–6) ||  || 32,934 || 40–30 || W2
|- style="background:#fbb
| 71 || June 22 || @ [[2021 Chicago Cubs season|Cubs]] || 1–7 || [[Kyle Hendricks|Hendricks]] (10–4) || '''[[Eli Morgan|Morgan]]''' (0–2) ||  || 35,493 || 40–31 || L1
|- style="background:#bfb 
| 72 || June 24 || @ [[2021 Minnesota Twins season|Twins]] || 4–1 || '''[[Blake Parker|Parker]]''' (1–0) || [[Jorge Alcalá|Alcalá]] (1–2) || '''[[James Karinchak|Karinchak]]''' (9) || 18,812 || 41–31 || W1
|- style="background:#fbb
| 73 || June 25 || @ [[2021 Minnesota Twins season|Twins]] || 7–8 || [[Griffin Jax|Jax]] (1–0) || '''[[Nick Wittgren|Wittgren]]''' (2–2) || [[Hansel Robles|Robles]] (7) || 16,892 || 41–32 || L1
|- style="background:#bbb
| — || June 26 || @ [[2021 Minnesota Twins season|Twins]] || colspan=7 | ''Postponed (rain) make-up date September 14
|- style="background:#fbb
| 74 || June 27 || @ [[2021 Minnesota Twins season|Twins]] || 2–8 || [[J. A. Happ|Happ]] (4–3) || '''[[Sam Hentges|Hentges]]''' (1–2) ||  || 20,215 || 41–33 || L2
|- style="background:#bfb
| 75 || June 28 || [[2021 Detroit Tigers season|Tigers]] || 13–5 || '''[[Eli Morgan|Morgan]]''' (1–2) || [[Matt Manning|Manning]] (1–2) ||  || 13,128 || 42–33 || W1 
|- style="background:#bbb 
| — || June 29 || [[2021 Detroit Tigers season|Tigers]] || colspan=7 | ''Postponed (rain) make-up date June 30
|- style="background:#fbb 
| 76 || June 30 || [[2021 Detroit Tigers season|Tigers]] || 4–9 ((small|(7))) || [[Kyle Funkhouser|Funkhouser]] (2–0) || '''[[Bryan Shaw (baseball)|Shaw]]''' (2–3) ||  || &mdash; || 42–34 || L1
|- style="background:#fbb
| 77 || June 30 || [[2021 Detroit Tigers season|Tigers]] || 1–7 ((small|(7))) || [[Wily Peralta|Peralta]] (1–1) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–5) ||  || 11,627 || 42–35 || L2
|-
((Game log section end))
((Game log section start|hide=y|style=((Baseball secondary style|Cleveland Indians));|title=July: 9–15 (Home: 5–8; Away: 4–7)| #| Date| Opponent| Score| Win| Loss| Save| Attendance| Record| Streak))Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed -->
|- style="background:#fbb
| 78 || July 1 || [[2021 Houston Astros season|Astros]] || 2–7 || [[Framber Valdez|Valdez]] (5–1) || '''[[J. C. Mejía|Mejía]]''' (1–3) ||  || 13,772 || 42–36 || L3
|- style="background:#fbb
| 79 || July 2 || [[2021 Houston Astros season|Astros]] || 3–6 || [[Lance McCullers Jr.|McCullers Jr.]] (6–1) || '''[[Sam Hentges|Hentges]]''' (1–3) || [[Ryan Pressly|Pressly]] (13) || 24,337 || 42–37 || L4
|- style="background:#fbb
| 80 || July 3 || [[2021 Houston Astros season|Astros]] || 2–3 || [[Jake Odorizzi|Odorizzi]] (3–3)  || '''[[Eli Morgan|Morgan]]''' (1–3) || [[Ryan Pressly|Pressly]] (14) || 24,961 || 42–38 || L5
|- style="background:#fbb 
| 81 || July 4 || [[2021 Houston Astros season|Astros]] || 3–4 ((small|(10))) || [[Blake Taylor|Taylor]] (1–2) || '''[[Emmanuel Clase|Clase]]''' (3–3) || [[Brooks Raley|Raley]] (2) || 17,412 || 42–39 || L6
|- style="background:#fbb 
| 82 || July 5 || @ [[2021 Tampa Bay Rays season|Rays]] || 8–9 || [[Peter Fairbanks|Fairbanks]] (2–3) || '''[[Emmanuel Clase|Clase]]''' (3–4) || || 8,832 || 42–40 || L7
|- style="background:#bbb
| — || July 6 || @ [[2021 Tampa Bay Rays season|Rays]] || colspan=7 | ''Postponed (Tropical Storm Elsa) make-up date July 7
|- style="background:#fbb 
| 83 || July 7 || @ [[2021 Tampa Bay Rays season|Rays]] || 1–8 || [[Michael Wacha|Wacha]] (2–2) || '''[[J. C. Mejía|Mejía]]''' (1–4) ||  || &mdash; || 42–41 || L8
|- style="background:#fbb 
| 84 || July 7 || @ [[2021 Tampa Bay Rays season|Rays]] || 0–4 || [[Josh Fleming (baseball)|Fleming]] (7–4) || '''[[Sam Hentges|Hentges]]''' (1–4) ||  || 10,905 || 42–42 || L9
|- style="background:#bfb
| 85 || July 8 || [[2021 Kansas City Royals season|Royals]] || 7–4 || '''[[James Karinchak|Karinchak]]''' (5–2) || [[Greg Holland|Holland]] (2–4) ||  || 13,272 || 43–42 || W1
|- style="background:#bfb
| 86 || July 9 || [[2021 Kansas City Royals season|Royals]] || 2–1 || '''[[James Karinchak|Karinchak]]''' (6–2) || [[Jake Brentz|Brentz]] (2–2) ||  || 21,395 || 44–42 || W2
|- style="background:#bfb
| 87 || July 10 || [[2021 Kansas City Royals season|Royals]] || 14–6 || '''[[Cal Quantrill|Quantrill]]''' (1–2) || [[Mike Minor (baseball)|Minor]] (6–8) ||  || 24,077 || 45–42 || W3
|- style="background:#bbb
| — || July 11 || [[2021 Kansas City Royals season|Royals]] || colspan=7 | ''Postponed (rain) make-up date September 20
|- style="text-align:center; background:#bbcaff;"
| colspan="11" | '''[[2021 Major League Baseball All-Star Game|91st All-Star Game: Denver, CO]]'''
|- style="background:#fbb;" 
| 88 || July 16 || @ [[2021 Oakland Athletics season|Athletics]] || 4–5 || [[Sergio Romo|Romo]] (1–0) || '''[[Emmanuel Clase|Clase]]''' (3–5) ||  || 12,361 || 45–43 || L1
|- style="background:#bfb 
| 89 || July 17 || @ [[2021 Oakland Athletics season|Athletics]] || 3–2 || '''[[Cal Quantrill|Quantrill]]''' (2–2) || [[Frankie Montas|Montas]] (8–8) || '''[[James Karinchak|Karinchak]]''' (10) || 11,374 || 46–43 || W1
|- style="background:#bfb 
| 90 || July 18 || @ [[2021 Oakland Athletics season|Athletics]] || 4–2 || '''[[Zach Plesac|Plesac]]''' (5–3) || [[Chris Bassitt|Bassitt]] (10–3) || '''[[Bryan Shaw (baseball)|Shaw]]''' (2) || 8,572 || 47–43 || W2
|- style="background:#fbb 
| 91 || July 19 || @ [[2021 Houston Astros season|Astros]] || 3–4 || [[Zack Greinke|Greinke]] (9–3) || '''[[J. C. Mejía|Mejía]]''' (1–5) || [[Ryan Pressly|Pressly]] (17) || 21,963 || 47–44 || L1
|- style="background:#fbb
| 92 || July 20 || @ [[2021 Houston Astros season|Astros]] || 3–9 || [[Luis García (pitcher, born 1996)|García]] (7–5) || '''[[Triston McKenzie|McKenzie]]''' (1–4) ||  || 26,586 || 47–45 || L2
|- style="background:#bfb 
| 93 || July 21 || @ [[2021 Houston Astros season|Astros]] || 5–4 || '''[[Bryan Shaw (baseball)|Shaw]]''' (3–3) || [[Austin Pruitt|Pruitt]] (0–1) || '''[[James Karinchak|Karinchak]]''' (11) || 21,712 || 48–45 || W1
|- style="background:#fbb 
| 94 || July 22 || [[2021 Tampa Bay Rays season|Rays]] || 4–5 ((small|(10))) || [[Pete Fairbanks|Fairbanks]] (3–3) || '''[[Bryan Shaw (baseball)|Shaw]]''' (3–4) || [[Diego Castillo (pitcher)|Castillo]] (14) || 19,338 || 48–46 || L1
|- style="background:#fbb 
| 95 || July 23 || [[2021 Tampa Bay Rays season|Rays]] || 5–10 || [[Matt Wisler|Wisler]] (3–3) || '''[[Nick Wittgren|Wittgren]]''' (2–3) ||  || 23,180 || 48–47 || L2
|- style="background:#fbb
| 96 || July 24 || [[2021 Tampa Bay Rays season|Rays]] || 2–8 || [[Louis Head|Head]] (1–0) || '''[[J. C. Mejía|Mejía]]''' (1–6) ||  || 23,194 || 48–48 || L3
|- style="background:#bfb 
| 97 || July 25 || [[2021 Tampa Bay Rays season|Rays]] || 3–2 || '''[[James Karinchak|Karinchak]]''' (7–2) || [[Matt Wisler|Wisler]] (3–4) || '''[[Emmanuel Clase|Clase]]''' (12) || 18,614 || 49–48 || W1
|- style="background:#fbb
| 98 || July 27 || [[2021 St. Louis Cardinals season|Cardinals]] || 2–4 || [[Adam Wainwright|Wainwright]] (8–6) || '''[[Bryan Shaw (baseball)|Shaw]]''' (3–5) || [[Alex Reyes|Reyes]] (24) || 19,480 || 49–49 || L1
|- style="background:#bfb 
| 99 || July 28 || [[2021 St. Louis Cardinals season|Cardinals]] || 7–2 || '''[[Zach Plesac|Plesac]]''' (6–3) || [[Kwang-hyun Kim|Kim]] (6–6) ||  || 19,927 || 50–49 || W1
|- style="background:#fbb 
| 100 || July 30 || @ [[2021 Chicago White Sox season|White Sox]] || 4–6 || [[José Ruiz (baseball)|Ruiz]] (1–1) || '''[[James Karinchak|Karinchak]]''' (7–3) || [[Liam Hendriks|Hendriks]] (26) || 36,123 || 50–50 || L1
|- style="background:#bfb
| 101 || July 31 || @ [[2021 Chicago White Sox season|White Sox]] || 12–11 || '''[[Justin Garza|Garza]]''' (1–0) || [[Michael Kopech|Kopech]] (3–1) || '''[[Emmanuel Clase|Clase]]''' (13) || 35,866 || 51–50 || W1
|-
((Game log section end))
((Game log section start|hide=y|style=((Baseball secondary style|Cleveland Indians));|title=August: 14–14 (Home: 9–7; Away: 5–7)| #| Date| Opponent| Score| Win| Loss| Save| Attendance| Record| Streak))Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed -->
|- style="background:#fbb 
| 102 || August 1 || @ [[2021 Chicago White Sox season|White Sox]] || 1–2 || [[Liam Hendriks|Hendriks]] (5–2) || '''[[Nick Wittgren|Wittgren]]''' (2–4) ||  || 34,344 || 51–51 || L1
|- style="background:#bfb 
| 103 || August 2 || @ [[2021 Toronto Blue Jays season|Blue Jays]] || 5–2 ((small|(10))) || '''[[Bryan Shaw (baseball)|Shaw]]''' (4–5) || [[Brad Hand|Hand]] (5–6) || '''[[Emmanuel Clase|Clase]]''' (14) || 14,653 || 52–51 || W1
|- style="background:#fbb 
| 104 || August 3 || @ [[2021 Toronto Blue Jays season|Blue Jays]] || 2–7 || [[Hyun-jin Ryu|Ryu]] (11–5) || '''[[Zach Plesac|Plesac]]''' (6–4) ||  || 14,270 || 52–52 || L1
|- style="background:#fbb
| 105 || August 4 || @ [[2021 Toronto Blue Jays season|Blue Jays]] || 6–8 || [[Steven Matz|Matz]] (9–6) || '''[[Jean Carlos Mejía|Mejía]]''' (1–7) ||  || 14,410 || 52–53 || L2
|- style="background:#fbb
| 106 || August 5 || @ [[2021 Toronto Blue Jays season|Blue Jays]] || 0–3 || [[Ross Stripling|Stripling]] (5–6) || '''[[Triston McKenzie|McKenzie]]''' (1–5) || [[Adam Cimber|Cimber]] (1) || 14,289 || 52–54 || L3
|- style="background:#bfb
| 107 || August 6 || [[2021 Detroit Tigers season|Tigers]] || 6–1 || '''[[Cal Quantrill|Quantrill]]''' (3–2) || [[Matt Manning|Manning]] (2–5) || '''[[Emmanuel Clase|Clase]]''' (15) || 24,485 || 53–54 || W1
|- style="background:#fbb 
| 108 || August 7 || [[2021 Detroit Tigers season|Tigers]] || 1–2 || [[Tyler Alexander|Alexander]] (2–1) || '''[[Eli Morgan|Morgan]]''' (1–4) || [[Gregory Soto|Soto]] (13) || 24,560 || 53–55 || L1
|- style="background:#bfb
| 109 || August 8 || [[2021 Detroit Tigers season|Tigers]] || 7–5 || '''[[Bryan Shaw (baseball)|Shaw]]''' (5–5) || [[Erasmo Ramírez (right-handed pitcher)|Ramírez]] (1–1) || '''[[Emmanuel Clase|Clase]]''' (16) || 19,899 || 54–55 || W1
|- style="background:#bfb
| 110 || August 9 || [[2021 Cincinnati Reds season|Reds]] || 9–3 || '''[[Justin Garza|Garza]]''' (2–0) || [[Luis Castillo (pitcher, born 1992)|Castillo]] (6–11) ||  || 10,708 || 55–55 || W2
|- style="background:#fbb 
| 111 || August 10 || [[2021 Oakland Athletics season|Athletics]] || 3–4 ((small|(10))) || [[Lou Trivino|Trivino]] (5–4) || '''[[Nick Wittgren|Wittgren]]''' (2–5) || [[Andrew Chafin|Chafin]] (1) || 13,041 || 55–56 || L1
|- style="background:#fbb 
| 112 || August 11 || [[2021 Oakland Athletics season|Athletics]] || 3–6 || [[Jake Diekman|Diekman]] (3–2) || '''[[Nick Sandlin|Sandlin]]''' (1–1) || [[Lou Trivino|Trivino]] (19) || 13,560 || 55–57 || L2
|- style="background:#fbb 
| 113 || August 12 || [[2021 Oakland Athletics season|Athletics]] || 0–17 || [[Chris Bassitt|Bassitt]] (12–3) || '''[[Eli Morgan|Morgan]]''' (1–5) ||  || 16,559 || 55–58 || L3
|- style="background:#bfb
| 114 || August 13 || @ [[2021 Detroit Tigers season|Tigers]] || 7–4 || '''[[Zach Plesac|Plesac]]''' (7–4) || [[Tyler Alexander|Alexander]] (2–2) ||  || 22,107 || 56–58 || W1
|- style="background:#fbb 
| 115 || August 14 || @ [[2021 Detroit Tigers season|Tigers]] || 4–6 || [[Michael Fulmer|Fulmer]] (5–4) || '''[[Bryan Shaw (baseball)|Shaw]]''' (5–6) || [[Gregory Soto|Soto]] (15) || 32,845 || 56–59 || L1
|- style="background:#bfb
| 116 || August 15 || @ [[2021 Detroit Tigers season|Tigers]] || 11–0 || '''[[Triston McKenzie|McKenzie]]''' (2–5) || [[Drew Hutchison (baseball)|Hutchinson]] (0–1) ||  || 25,684 || 57–59 || W1
|- style="background:#fbb 
| 117 || August 16 || @ [[2021 Minnesota Twins season|Twins]] || 4–5 ((small|(10))) || [[Caleb Thielbar|Thielbar]] (5–0) || '''[[Nick Wittgren|Wittgren]]''' (2–6) ||  || 15,622 || 57–60 || L1
|- style="background:#bfb 
| 118 || August 17 || @ [[2021 Minnesota Twins season|Twins]] || 3–1 || '''[[Eli Morgan|Morgan]]''' (2–5) || [[Bailey Ober|Ober]] (1–2) || '''[[Emmanuel Clase|Clase]]''' (17) || 19,605 || 58–60 || W1
|- style="background:#fbb 
| 119 || August 18 || @ [[2021 Minnesota Twins season|Twins]] || 7–8 ((small|(11))) || [[Danny Coulombe|Coulombe]] (3–1) || '''[[Justin Garza|Garza]]''' (2–1) ||  || 19,949 || 58–61 || L1
|- style="background:#bfb
| 120 || August 20 || [[2021 Los Angeles Angels season|Angels]] || 9–1 || '''[[Trevor Stephan|Stephan]]''' (2–0) || [[Jaime Barría|Barría]] (2–2) ||  || 22,755 || 59–61 || W1
|- style="background:#bfb
| 121 || August 21 || [[2021 Los Angeles Angels season|Angels]] || 5–1 || '''[[Triston McKenzie|McKenzie]]''' (3–5) || [[Reid Detmers|Detmers]] (1–3) ||  || 31,406 || 60–61 || W2
|- style="background:#bfb
| 122 || [[2021 MLB Little League Classic|August 22]] || [[2021 Los Angeles Angels season|Angels]] || 3–0 || '''[[Cal Quantrill|Quantrill]]''' (4–2) || [[José Suárez (baseball, born 1998)|Suarez]] (5–7) || '''[[Emmanuel Clase|Clase]]''' (18) || 1,832 || 61–61 || W3
|- style="background:#fbb
| 123 || August 24 || [[2021 Texas Rangers season|Rangers]] || 3–7 || [[Taylor Hearn (baseball)|Hearn]] (3–4) || '''[[Eli Morgan|Morgan]]''' (2–6) ||  || 11,369 || 61–62 || L1
|- style="background:#bfb
| 124 || August 25 || [[2021 Texas Rangers season|Rangers]] || 7–2 || '''[[Zach Plesac|Plesac]]''' (8–4) || [[Jake Latz|Latz]] (0–1) ||  || 11,398 || 62–62 || W1
|- style="background:#bfb 
| 125 || August 26 || [[2021 Texas Rangers season|Rangers]] || 10–6 || '''[[Trevor Stephan|Stephan]]''' (3–0) || [[Jordan Lyles|Lyles]] (6–11) || — || 10,827 || 63–62 || W2
|- style="background:#fbb 
| 126 || August 27 || [[2021 Boston Red Sox season|Red Sox]] || 3–4 || [[Eduardo Rodriguez (left-handed pitcher)|Rodriguez]] (10–7) || '''[[James Karinchak|Karinchak]]''' (7–4) || [[Adam Ottavino|Ottavino]] (9) || 20,881 || 63–63 || L1
|- style="background:#fbb
| 127 || August 28 || [[2021 Boston Red Sox season|Red Sox]] || 3–5 ((small|(10))) || [[Garrett Whitlock|Whitlock]] (6–2) || '''[[Nick Wittgren|Wittgren]]''' (2–7) || [[Adam Ottavino|Ottavino]] (10) || 26,221 || 63–64 || L2
|- style="background:#bfb 
| 128 || August 29 || [[2021 Boston Red Sox season|Red Sox]] || 7–5 || '''[[Bryan Shaw (baseball)|Shaw]]''' (6–6) || [[Austin Davis (baseball)|Davis]] (0–2) || '''[[Emmanuel Clase|Clase]]''' (19) || 22,883 || 64–64 || W1
|- style="background:#bfb 
| 129 || August 31 || @ [[2021 Kansas City Royals season|Royals]] || 7–2 || '''[[Zach Plesac|Plesac]]''' (9–4) || [[Jakob Junis|Junis]] (2–4) || — || 11,542 || 65–64 || W2
|-
((Game log section end))
((Game log section start|hide=y|style=((Baseball secondary style|Cleveland Indians));|title=September/October: 15–18 (Home: 5–11; Away: 10–7)| #| Date| Opponent| Score| Win| Loss| Save| Attendance| Record| Streak))Use background:#fbb for loss, #bfb for win, #bbb for cancelled/postponed -->
|- style="background:#bfb
| 130 || September 1 || @ [[2021 Kansas City Royals season|Royals]] || 5–3 ((small|(11))) || '''[[Blake Parker|Parker]]''' (2–0) || [[Ervin Santana|Santana]] (1–2) || '''[[Trevor Stephan|Stephan]]''' (1) || 10,516 || 66–64 || W3
|- style="background:#bfb 
| 131 || September 2 || @ [[2021 Kansas City Royals season|Royals]] || 4–2 || '''[[Triston McKenzie|McKenzie]]''' (4–5) || [[Mike Minor (baseball)|Minor]] (8–12) || '''[[Emmanuel Clase|Clase]]''' (20) || 10,042 || 67–64 || W4
|- style="background:#fbb
| 132 || September 3 || @ [[2021 Boston Red Sox season|Red Sox]] || 5–8 || [[Adam Ottavino|Ottavino]] (4–3) || '''[[Cal Quantrill|Quantrill]]''' (4–3) || [[Garrett Whitlock|Whitlock]] (2)  || 31,127 || 67–65 || L1
|- style="background:#fbb 
| 133 || September 4 || @ [[2021 Boston Red Sox season|Red Sox]] || 3–4 || [[Adam Ottavino|Ottavino]] (5–3) || '''[[Bryan Shaw (baseball)|Shaw]]''' (6–7) ||  || 33,081 || 67–66 || L2 
|- style="background:#bfb
| 134 || September 5 || @ [[2021 Boston Red Sox season|Red Sox]] || 11–5 || '''[[Zach Plesac|Plesac]]''' (10–4) || [[Kutter Crawford|Crawford]] (0–1) || '''[[Emmanuel Clase|Clase]]''' (21) || 27,578 || 68–66 || W1
|- style="background:#fbb
| 135 || September 6 || [[2021 Minnesota Twins season|Twins]] || 2–5 || [[Michael Pineda|Pineda]] (5–8) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–6) || [[Álex Colomé|Colomé]] (12) || 12,675 || 68–67 || L1
|- style="background:#fbb 
| 136 || September 7 || [[2021 Minnesota Twins season|Twins]] || 0–3 || [[John Gant|Gant]] (5–9) || '''[[Aaron Civale|Civale]]''' (10–3) || [[Álex Colomé|Colomé]] (13) || 10,448 || 68–68 || L2
|- style="background:#fbb 
| 137 || September 8 || [[2021 Minnesota Twins season|Twins]] || 0–3 || [[Joe Ryan (baseball)|Ryan]] (1–1) || '''[[Triston McKenzie|McKenzie]]''' (4–6) || [[Tyler Duffey|Duffey]] (3) || 11,037 || 68–69 || L3
|- style="background:#bfb
| 138 || September 9 || [[2021 Minnesota Twins season|Twins]] || 4–1 || '''[[Cal Quantrill|Quantrill]]''' (5–3) || [[Andrew Albers|Albers]] (1–2) || '''[[Emmanuel Clase|Clase]]''' (22) || 11,846 || 69–69 || W1
|- style="background:#fbb 
| 139 || September 10 || [[2021 Milwaukee Brewers season|Brewers]] || 3–10 || [[Adrian Houser|Houser]] (9–6) || '''[[Eli Morgan|Morgan]]''' (2–7) ||  || 17,667 || 69–70 || L1
|- style="background:#fbb 
| 140 || September 11 || [[2021 Milwaukee Brewers season|Brewers]] || 0–3 || [[Corbin Burnes|Burnes]] (10–4) || '''[[Zach Plesac|Plesac]]''' (10–5) || [[Josh Hader|Hader]] (31) || 20,100 || 69–71 || L2
|- style="background:#fbb 
| 141 || September 12 || [[2021 Milwaukee Brewers season|Brewers]] || 1–11 || [[Eric Lauer|Lauer]] (6–5) || '''[[Aaron Civale|Civale]]''' (10–4) || [[Aaron Ashby|Ashby]] (1) || 16,332 || 69–72 || L3
|- style="background:#bfb 
| 142 || September 14 ((small|(G1))) || @ [[2021 Minnesota Twins season|Twins]] || 3–1 ((small|(7))) || '''[[Triston McKenzie|McKenzie]]''' (5–6) || [[Danny Coulombe|Coulombe]] (3–2) || '''[[Emmanuel Clase|Clase]]''' (23) || 15,319 || 70–72 || W1
|- style="background:#fbb
| 143 || September 14 ((small|(G2))) || @ [[2021 Minnesota Twins season|Twins]] || 3–6 ((small|(7))) || [[Kyle Barraclough|Barraclough]] (1–0) || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (1–7) || [[Álex Colomé|Colomé]] (14) || 18,905 || 70–73 || L1
|- style="background:#bfb 
| 144 || September 15 || @ [[2021 Minnesota Twins season|Twins]] || 12–3 || '''[[Cal Quantrill|Quantrill]]''' (6–3) || [[Griffin Jax|Jax]] (3–4) ||  || 14,222 || 71–73 || W1
|- style="background:#fbb 
| 145 || September 17 || @ [[2021 New York Yankees season|Yankees]] || 0–8 || [[Corey Kluber|Kluber]] (5–3) || '''[[Zach Plesac|Plesac]]''' (10–6) ||  || 31,403 || 71–74 || L1
|- style="background:#bfb 
| 146 || September 18 || @ [[2021 New York Yankees season|Yankees]] || 11–3 || '''[[Aaron Civale|Civale]]''' (11–4) || [[Luis Gil (baseball)|Gil]] (1–1) ||  || 39,088 || 72–74 || W1
|- style="background:#bfb 
| 147 || September 19 || @ [[2021 New York Yankees season|Yankees]] || 11–1 || '''[[Eli Morgan|Morgan]]''' (3–7) || [[Gerrit Cole|Cole]] (15–8) ||  || 34,110 || 73–74 || W2
|- style="background:#fbb 
| 148 || September 20 ((small|(G1))) || [[2021 Kansas City Royals season|Royals]] || 2–7 ((small|(7))) || [[Brady Singer|Singer]] (5–10) || '''[[Triston McKenzie|McKenzie]]''' (5–7) ||  || &mdash; || 73–75 || L1
|- style="background:#fbb
| 149 || September 20 ((small|(G2))) || [[2021 Kansas City Royals season|Royals]] || 2–4 ((small|(7))) || [[Domingo Tapia|Tapia]] (3–0) || '''[[Nick Wittgren|Wittgren]]''' (2–8) || [[Scott Barlow (baseball)|Barlow]] (14) || 11,459 || 73–76 || L2
|- style="background:#bfb
| 150 || September 21 || [[2021 Kansas City Royals season|Royals]] || 4–1 || '''[[Cal Quantrill|Quantrill]]''' (7–3) || [[Daniel Lynch (baseball)|Lynch]] (4–6) || '''[[Emmanuel Clase|Clase]]''' (24) || 23,341 || 74–76 || W1
|- style="background:#bbb
| — || September 22 || [[2021 Kansas City Royals season|Royals]] || colspan=7 | ''Postponed (rain) make-up date September 27
|- style="background:#fbb 
| 151 || September 23 ((small|(G1))) || [[2021 Chicago White Sox season|White Sox]] || 2–7 ((small|(7))) || [[Aaron Bummer|Bummer]] (4–5) || '''[[Aaron Civale|Civale]]''' (11–5) || — || 11,851 || 74–77 || L1
|- style="background:#bfb 
| 152 || September 23 ((small|(G2))) || [[2021 Chicago White Sox season|White Sox]] || 5–3 ((small|(7))) || '''[[Emmanuel Clase|Clase]]''' (4–5) || [[José Ruiz (baseball)|Ruiz]] (1–3) ||  || 11,336 || 75–77 || W1
|- style="background:#fbb
| 153 || September 24 || [[2021 Chicago White Sox season|White Sox]] || 0–1 || [[Dylan Cease|Cease]] (13–7) || '''[[Trevor Stephan|Stephan]]''' (3–1) || [[Liam Hendriks|Hendriks]] (35) || 18,576 || 75–78 || L1
|- style="background:#bfb
| 154 || September 25 || [[2021 Chicago White Sox season|White Sox]] || 6–0 || '''[[Eli Morgan|Morgan]]''' (4–7) || [[Lance Lynn|Lynn]] (10–6) ||  || 24,082 || 76–78 || W1
|- style="background:#fbb
| 155 || September 26 || [[2021 Chicago White Sox season|White Sox]] || 2–5 || [[Lucas Giolito|Giolito]] (11–9) || '''[[Triston McKenzie|McKenzie]]''' (5–8) || [[Liam Hendriks|Hendriks]] (36) || 21,957 || 76–79 || L1
|- style="background:#bfb 
| 156 || September 27 || [[2021 Kansas City Royals season|Royals]] || 8–3 || '''[[Cal Quantrill|Quantrill]]''' (8–3) || [[Jackson Kowar|Kowar]] (0–5) ||  || 13,121 || 77–79 || W1
|- style="background:#fbb 
| 157 || September 28 || @ [[2021 Kansas City Royals season|Royals]] || 4–6 || [[Josh Staumont|Staumont]] (4–3) || '''[[Blake Parker|Parker]]''' (2–1) ||  || 11,670 || 77–80 || L1
|- style="background:#fbb 
| 158 || September 29 || @ [[2021 Kansas City Royals season|Royals]] || 5–10 || [[Greg Holland|Holland]] (3–5) || '''[[Nick Wittgren|Wittgren]]''' (2–9) ||  || 10,373 || 77–81 || L2
|- style="background:#bfb 
| 159 || September 30 || @ [[2021 Kansas City Royals season|Royals]] || 6–1 || '''[[Logan Allen (baseball, born 1997)|Allen]]''' (2–7) || [[Ángel Zerpa|Zerpa]] (0–1) ||  || 11,288 || 78–81 || W1
|- style="background:#bfb 
| 160 || October 1 || @ [[2021 Texas Rangers season|Rangers]] || 9–6 || '''[[Eli Morgan|Morgan]]''' (5–7) || [[Spencer Howard|Howard]] (0–5) ||  || 22,700 || 79–81 || W2
|- style="background:#fbb 
| 161 || October 2 || @ [[2021 Texas Rangers season|Rangers]] || 2–7 || [[Jordan Lyles|Lyles]] (10–13) || '''[[Triston McKenzie|McKenzie]]''' (5–9) ||  || 27,362 || 79–82 || L1
|- style="background:#bfb
| 162 || October 3 || @ [[2021 Texas Rangers season|Rangers]] || 6–0 || '''[[Aaron Civale|Civale]]''' (12–5) || [[Dane Dunning|Dunning]] (5–10) ||  || 28,396 || 80–82 || W1
|-
((Game log section end))
|- style="text-align:center;"
| ''Legend:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ((Color box|#cfc|border=darkgray)) = Win&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ((Color box|#fbb|border=darkgray)) = Loss&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; ((Color box|#bbb|border=darkgray)) = Postponement<br>Bold = Indians team member''
((Game log end))

==Player stats==
===Batting===
''Note: G = Games played; AB = At bats; R = Runs; H = Hits; 2B = Doubles; 3B = Triples; HR = Home runs; RBI = Runs batted in; AVG = Batting average; SB = Stolen bases''
{| class="wikitable" style="text-align:center;"
|-
!  style="background:#ddf; width:18%;"| '''Player'''
!  style="background:#ddf; width:7%;"| '''G'''
!  style="background:#ddf; width:7%;"| '''AB'''
!  style="background:#ddf; width:7%;"| '''R'''
!  style="background:#ddf; width:7%;"| '''H'''
!  style="background:#ddf; width:7%;"| '''2B'''
!  style="background:#ddf; width:7%;"| '''3B'''
!  style="background:#ddf; width:7%;"| '''HR'''
!  style="background:#ddf; width:7%;"| '''RBI'''
!  style="background:#ddf; width:7%;"| '''AVG'''
!  style="background:#ddf; width:7%;"| '''SB'''
|-
| align=left | ((sortname|Logan|Allen|dab=baseball, born 1997))
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Jake|Bauers))
| 43
| 100
| 7
| 19
| 3
| 0
| 2
| 6
| .190
| 0
|-
| align=left | ((sortname|Shane|Bieber))
| 2
| 6
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Bobby|Bradley|Bobby Bradley (first baseman)))
| 74
| 245
| 36
| 51
| 10
| 0
| 16
| 41
| .208
| 0
|-
| align=left | ((sortname|Yu|Chang))
| 89
| 237
| 32
| 54
| 14
| 3
| 9
| 39
| .228
| 1
|-
| align=left | ((sortname|Aaron|Civale))
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Emmanuel|Clase))
| 5
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Ernie|Clement))
| 40
| 121
| 16
| 28
| 4
| 0
| 3
| 9
| .231
| 0
|-
| align=left | ((sortname|Ben|Gamel))
| 11
| 14
| 1
| 1
| 1
| 0
| 0
| 0
| .071
| 0
|-
| align=left | ((sortname|Andrés|Giménez))
| 68
| 188
| 23
| 41
| 10
| 0
| 5
| 16
| .218
| 11
|-
| align=left | ((sortname|Austin|Hedges))
| 88
| 286
| 32
| 51
| 7
| 0
| 10
| 31
| .178
| 1
|-
| align=left | ((sortname|Sam|Hentges))
| 1
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Cesar|Hernandez|Cesar Hernandez (infielder)))
| 96
| 376
| 60
| 87
| 17
| 2
| 18
| 47
| .231
| 0
|-
| align=left | ((sortname|Daniel|Johnson|Daniel Johnson (baseball)))
| 30
| 77
| 9
| 17
| 0
| 0
| 4
| 5
| .221
| 1
|-
| align=left | ((sortname|James|Karinchak))
| 6
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Ryan|Lavarnway))
| 9
| 28
| 2
| 7
| 3
| 0
| 0
| 0
| .250
| 0
|-
| align=left | ((sortname|Jordan|Luplow))
| 36
| 98
| 12
| 17
| 5
| 0
| 7
| 20
| .173
| 0
|-
| align=left | ((sortname|Phil|Maton))
| 4
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Triston|McKenzie))
| 1
| 2
| 0
| 1
| 0
| 0
| 0
| 0
| .500
| 0
|-
| align=left | ((sortname|Jean Carlos|Mejía))
| 2
| 1
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Oscar|Mercado))
| 72
| 214
| 27
| 48
| 11
| 1
| 6
| 19
| .224
| 7
|-
| align=left | ((sortname|Owen|Miller))
| 60
| 191
| 17
| 39
| 8
| 0
| 4
| 18
| .204
| 2
|-
| align=left | ((sortname|Eli|Morgan))
| 1
| 2
| 0
| 0
| 0
| 0
| 0
| 0
| .000
| 0
|-
| align=left | ((sortname|Josh|Naylor))
| 69
| 233
| 28
| 59
| 13
| 0
| 7
| 21
| .253
| 1
|-
| align=left | ((sortname|Kyle|Nelson|Kyle Nelson (baseball)))
| 2
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Blake|Parker))
| 4
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Oliver|Perez))
| 2
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Roberto|Perez))
| 44
| 141
| 13
| 21
| 3
| 0
| 7
| 17
| .149
| 1
|-
| align=left | ((sortname|Cal|Quantrill))
| 3
| 2
| 0
| 1
| 0
| 0
| 0
| 0
| .500
| 0
|-
| align=left | ((sortname|Harold|Ramírez))
| 99
| 339
| 33
| 91
| 21
| 1
| 7
| 42
| .268
| 3
|-
| align=left | ((sortname|Jose|Ramirez|Jose Ramirez (infielder)))
| 152
| 552
| 111
| 147
| 32
| 5
| 36
| 103
| .266
| 27
|-
| align=left | ((sortname|Wilson|Ramos))
| 9
| 31
| 3
| 7
| 0
| 0
| 2
| 7
| .226
| 0
|-
| align=left | ((sortname|Franmil|Reyes))
| 115
| 418
| 57
| 106
| 18
| 2
| 30
| 85
| .254
| 4
|-
| align=left | ((sortname|Rene|Rivera))
| 21
| 55
| 6
| 13
| 3
| 0
| 2
| 9
| .236
| 0
|-
| align=left | ((sortname|Amed|Rosario))
| 141
| 550
| 77
| 155
| 25
| 6
| 11
| 57
| .282
| 13
|-
| align=left | ((sortname|Eddie|Rosario))
| 78
| 283
| 29
| 72
| 15
| 1
| 7
| 46
| .254
| 9
|-
| align=left | ((sortname|Nick|Sandlin))
| 3
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Bryan|Shaw|Bryan Shaw (baseball)))
| 4
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Trevor|Stephan))
| 4
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Myles|Straw))
| 60
| 239
| 42
| 68
| 16
| 0
| 2
| 14
| .285
| 13
|-
| align=left | ((sortname|Nick|Wittgren))
| 3
| 0
| 0
| 0
| 0
| 0
| 0
| 0
| &mdash;
| 0
|-
| align=left | ((sortname|Bradley|Zimmer))
| 99
| 299
| 44
| 68
| 9
| 1
| 8
| 35
| .227
| 15
|- class="sortbottom"
| '''Team Totals'''
| '''162'''
| '''5332'''
| '''717'''
| '''1269'''
| '''248'''
| '''22'''
| '''203'''
| '''686''' 
| '''.238'''
| '''109'''
|}

===Pitching===
''Note: W = Wins; L = Losses; ERA = Earned run average; G = Games pitched; GS = Games started; SV = Saves; IP = Innings pitched; H = Hits allowed; R = Total runs allowed; ER = Earned runs allowed; BB = Walks allowed; K = Strikeouts''
{| class="wikitable" style="text-align:center;"
|-
!  style="background:#ddf; width:18%;"| '''Player'''
!  style="background:#ddf; width:7%;"| '''W'''
!  style="background:#ddf; width:7%;"| '''L'''
!  style="background:#ddf; width:7%;"| '''ERA'''
!  style="background:#ddf; width:7%;"| '''G'''
!  style="background:#ddf; width:7%;"| '''GS'''
!  style="background:#ddf; width:7%;"| '''SV'''
!  style="background:#ddf; width:7%;"| '''IP'''
!  style="background:#ddf; width:7%;"| '''H'''
!  style="background:#ddf; width:7%;"| '''R'''
!  style="background:#ddf; width:7%;"| '''ER'''
!  style="background:#ddf; width:7%;"| '''BB'''
!  style="background:#ddf; width:7%;"| '''K'''
|-
| align=left | ((sortname|Logan|Allen|dab=baseball, born 1997))
| 2
| 7
| 6.26
| 14
| 11
| 0
| 50.1
| 58
| 39
| 35
| 17
| 37
|-
| align=left | ((sortname|Shane|Bieber))
| 7
| 4
| 3.17
| 16
| 16
| 0
| 96.2
| 84
| 36
| 34
| 33
| 134
|-
| align=left | ((sortname|Aaron|Civale))
| 12
| 5
| 3.84
| 21
| 21
| 0
| 124.1
| 108
| 56
| 53
| 31
| 99
|-
| align=left | ((sortname|Emmanuel|Clase))
| 4
| 5
| 1.29
| 71
| 0
| 24
| 69.2
| 51
| 18
| 10
| 16
| 74
|-
| align=left | ((sortname|Justin|Garza))
| 2
| 1
| 4.71
| 21
| 0
| 0
| 28.2
| 27
| 16
| 15
| 18
| 29
|-
| align=left | ((sortname|Anthony|Gose))
| 0
| 0
| 1.35
| 6
| 0
| 0
| 6.2
| 2
| 1
| 1
| 2
| 9
|-
| align=left | ((sortname|Sam|Hentges))
| 1
| 4
| 6.68
| 30
| 12
| 0
| 68.2
| 90
| 54
| 51
| 32
| 68
|-
| align=left | ((sortname|D. J.|Johnson|D. J. Johnson (baseball)))
| 0
| 0
| 5.40
| 1
| 0
| 0
| 1.2
| 2
| 1
| 1
| 0
| 3
|-
| align=left | ((sortname|James|Karinchak))
| 7
| 4
| 4.07
| 60
| 0
| 11
| 55.1
| 35
| 27
| 25
| 32
| 78
|-
| align=left | ((sortname|Phil|Maton))
| 2
| 0
| 4.57
| 38
| 1
| 0
| 41.1
| 36
| 21
| 21
| 20
| 61
|-
| align=left | ((sortname|Triston|McKenzie))
| 5
| 9
| 4.95
| 25
| 24
| 0
| 120.0
| 84
| 66
| 66
| 58
| 136
|-
| align=left | ((sortname|Jean Carlos|Mejía))
| 1
| 7
| 8.25
| 17
| 11
| 0
| 52.1
| 60
| 48
| 48
| 24
| 47
|-
| align=left | ((sortname|Eli|Morgan))
| 5
| 7
| 5.34
| 18
| 18
| 0
| 89.1
| 90
| 54
| 53
| 22
| 81
|-
| align=left | ((sortname|Kyle|Nelson|Kyle Nelson (baseball)))
| 0
| 0
| 9.31
| 10
| 0
| 0
| 9.2
| 10
| 10
| 10
| 8
| 8
|-
| align=left | ((sortname|Blake|Parker))
| 2
| 1
| 3.09
| 47
| 0
| 0
| 43.2
| 43
| 15
| 15
| 14
| 37
|-
| align=left | ((sortname|Francisco|Pérez|Francisco Pérez (baseball)))
| 0
| 0
| 4.05
| 4
| 0
| 0
| 6.2
| 6
| 3
| 3
| 3
| 5
|-
| align=left | ((sortname|Oliver|Perez))
| 0
| 1
| 0.00
| 5
| 0
| 0
| 3.2
| 5
| 1
| 0
| 1
| 4
|-
| align=left | ((sortname|Zach|Plesac))
| 10
| 6
| 4.67
| 25
| 25
| 0
| 142.2
| 137
| 79
| 74
| 34
| 100
|-
| align=left | ((sortname|Cal|Quantrill))
| 8
| 3
| 2.89
| 40
| 22
| 0
| 149.2
| 129
| 55
| 48
| 47
| 121
|-
| align=left | ((sortname|Nick|Sandlin))
| 1
| 1
| 2.94
| 34
| 0
| 0
| 33.2
| 21
| 15
| 11
| 17
| 48
|-
| align=left | ((sortname|Bryan|Shaw|Bryan Shaw (baseball)))
| 6
| 7
| 3.49
| 81
| 0
| 2
| 77.1
| 69
| 33
| 30
| 38
| 71
|-
| align=left | ((sortname|Trevor|Stephan))
| 3
| 1
| 4.41
| 43
| 0
| 1
| 63.1
| 58
| 32
| 31
| 31
| 75
|-
| align=left | ((sortname|Nick|Wittgren))
| 2
| 9
| 5.05
| 60
| 1
| 1
| 62.1
| 61
| 38
| 35
| 17
| 61
|-
| align=left | ((sortname|Alex|Young|Alex Young (baseball)))
| 0
| 0
| 7.84
| 10
| 0
| 0
| 10.1
| 15
| 9
| 9
| 7
| 5
|- class="sortbottom"
| '''Team Totals'''
| '''80'''
| '''82''' 
| '''4.34'''
| '''162'''
| '''162'''
| '''39'''
| '''1408.0'''
| '''1281'''
| '''727'''
| '''679'''
| '''522'''
| '''1391'''
|}

==Roster==
{| class="toccolours" style="font-size: 95%;"
|-
! colspan="10" style="((Baseball primary style|Cleveland Indians)); text-align: center;" |2021 Cleveland Indians
|-
| colspan="10" style="((Baseball secondary style|Cleveland Indians)); text-align: center;" | '''Roster'''
|-
| valign="top" | '''Pitchers'''
((MLBplayer|54|[[Logan Allen (baseball, born 1997)|Logan Allen]]))
((MLBplayer|57|[[Shane Bieber]]))
((MLBplayer|43|[[Aaron Civale]]))
((MLBplayer|48|[[Emmanuel Clase]]))
((MLBplayer|63|[[Justin Garza]]))
((MLBplayer|26|[[Anthony Gose]]))
((MLBplayer|31|[[Sam Hentges]]))
((MLBplayer|56|[[DJ Johnson (baseball)|DJ Johnson]]))
((MLBplayer|99|[[James Karinchak]]))
((MLBplayer|88|[[Phil Maton]]))
((MLBplayer|24|[[Triston McKenzie]]))
((MLBplayer|36|[[J. C. Mejía]]))
((MLBplayer|49|[[Eli Morgan]]))
((MLBplayer|30|[[Kyle Nelson (baseball)|Kyle Nelson]]))
((MLBplayer|53|[[Blake Parker]]))
((MLBplayer|65|[[Francisco Pérez (baseball)|Francisco Pérez]]))
((MLBplayer|39|[[Óliver Pérez]]))
((MLBplayer|34|[[Zach Plesac]]))
((MLBplayer|47|[[Cal Quantrill]]))
((MLBplayer|52|[[Nick Sandlin]]))
((MLBplayer|27|[[Bryan Shaw (baseball)|Bryan Shaw]]))
((MLBplayer|37|[[Trevor Stephan]]))
((MLBplayer|62|[[Nick Wittgren]]))
((MLBplayer|46|[[Alex Young (baseball)|Alex Young]]))
| width="25px" |
| valign="top" | '''Catchers'''
((MLBplayer|17|[[Austin Hedges]]))
((MLBplayer|50|[[Ryan Lavarnway]]))
((MLBplayer|55|[[Roberto Pérez]]))
((MLBplayer|40|[[Wilson Ramos]]))
((MLBplayer|46|[[René Rivera]]))
'''Infielders'''
((MLBplayer|10|[[Jake Bauers]]))
((MLBplayer|44|[[Bobby Bradley (first baseman)|Bobby Bradley]]))
((MLBplayer|&nbsp;2|[[Yu Chang]]))
((MLBplayer|28|[[Ernie Clement]]))
((MLBplayer|&nbsp;0|[[Andrés Giménez]]))
((MLBplayer|&nbsp;7|[[César Hernández (infielder)|César Hernández]]))
((MLBplayer|&nbsp;6|[[Owen Miller]]))
((MLBplayer|11|[[José Ramírez (infielder)|José Ramírez]]))
((MLBplayer|&nbsp;1|[[Amed Rosario]]))
| width="25px" |
| valign="top" | '''Outfielders'''
((MLBplayer|28|[[Ben Gamel]]))
((MLBplayer|23|[[Daniel Johnson (baseball)|Daniel Johnson]]))
((MLBplayer|&nbsp;8|[[Jordan Luplow]]))
((MLBplayer|35|[[Oscar Mercado]]))
((MLBplayer|22|[[Josh Naylor]]))
((MLBplayer|40|[[Harold Ramírez]]))
((MLBplayer|32|[[Franmil Reyes]]))
((MLBplayer|&nbsp;9|[[Eddie Rosario]]))
((MLBplayer|&nbsp;7|[[Myles Straw]]))
((MLBplayer|&nbsp;4|[[Bradley Zimmer]]))
| width="25px" |
| valign="top" |'''Manager'''
((MLBplayer|77|[[Terry Francona]]))
((MLBplayer|33|[[DeMarlo Hale]])) 
'''Coaches'''
((MLBplayer|15|[[Sandy Alomar Jr.]])) ((small|(first base/catchers)))
((MLBplayer|87|[[Mike Barnett (baseball)|Mike Barnett]])) ((small|(assistant coach/replays)))
((MLBplayer|64|Armando Camacaro)) ((small|(bullpen catcher/staff assistant)))
((MLBplayer|33|[[DeMarlo Hale]])) ((small|(bench)))
((MLBplayer|97|[[Kyle Hudson]])) ((small|(third base)))
((MLBplayer|58|[[Ruben Niebla]])) ((small|(assistant pitching)))
((MLBplayer|82|Ricky Pacione)) ((small|(bullpen catcher/staff assistant)))
((MLBplayer|60|[[Vic Rodriguez (baseball)|Vic Rodriguez]])) ((small|(assistant hitting)))
((MLBplayer|16|[[Mike Sarbaugh]])) ((small|(bench)))
((MLBplayer|85|[[Brian Sweeney]])) ((small|(bullpen)))
((MLBplayer|96|Justin Toole)) ((small|(hitting analyst)))
((MLBplayer|29|[[Ty Van Burkleo]])) ((small|(hitting)))
((MLBplayer|51|[[Carl Willis]])) ((small|(pitching)))

|}

==Farm system==
((See also|Minor League Baseball))

((MLB Farm System|level11=[[Triple-A (baseball)|AAA]]|team11=[[Columbus Clippers]]|league11=[[Triple-A East]]|manager11=Andy Tracy
|level12=[[Double-A (baseball)|AA]] |team12=[[Akron RubberDucks]]|league12=[[Double-A Northeast]]|manager12=[[Rouglas Odor]]
|level13=[[High-A]]  |team13=[[Lake County Captains]]|league13=[[High-A Central]]|manager13=[[Greg DiCenzo]]
|level14=[[Class A (baseball)|A]]  |team14=[[Lynchburg Hillcats]]|league14=[[Low-A East]]|manager14=Dennis Malave
|level17=[[Rookie League|Rookie]]|team17=[[Arizona Complex League Indians|ACL Indians]]|league17=[[Arizona Complex League]]|manager17=  [[Jerry Owens]]
|level19=[[Rookie League|Rookie]]|team19=[[Dominican Summer League Indians|DSL Indians]]|league19=[[Dominican Summer League]]|manager19= Jesus Tavares
))

==References==
((reflist|30em))

==External links==
*[https://www.mlb.com/indians/schedule/2021/fullseason Cleveland Indians 2021 Schedule] at MLB.com
*[https://www.baseball-reference.com/teams/CLE/2021-schedule-scores.shtml 2021 Cleveland Indians season] at ''Baseball Reference''

((2021 MLB season by team))
((Cleveland Guardians))

[[Category:Cleveland Guardians seasons]]
[[Category:2021 Major League Baseball season|Cleveland]]
[[Category:2021 in sports in Ohio|Cleveland Indians]]

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2021 Cleveland Indians season (edit)
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Retrieved from "https://en.wikipedia.org/wiki/2021_Cleveland_Indians_season"