Clinical data
Routes of
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class A
  • US: Unscheduled
Pharmacokinetic data
Elimination half-life1-2 hrs
  • 3-[2-(diisopropylamino)ethyl]-1H-indol-4-ol
CAS Number
CompTox Dashboard (EPA)
ECHA InfoCard100.214.853 Edit this at Wikidata
Chemical and physical data
Molar mass260.381 g·mol−1
3D model (JSmol)
  • CC(C)N(CCc1c[nH]c2cccc(O)c12)C(C)C
  • InChI=1S/C16H24N2O/c1-11(2)18(12(3)4)9-8-13-10-17-14-6-5-7-15(19)16(13)14/h5-7,10-12,17,19H,8-9H2,1-4H3 checkY
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4-HO-DiPT Powder
4-HO-DiPT Powder

4-Hydroxy-N,N-diisopropyltryptamine (4-HO-DiPT or Iprocin) is a synthetic psychedelic drug. It is a higher homologue of psilocin, 4-HO-DET, and is a positional isomer of 4-HO-DPT and has a tryptamine molecular sub-structure.


4-HO-DiPT is orally active at around 3 mg and above, and its effects last for 2–3 hours.[1] Higher doses such as those above 30 mgs can increase the duration of the effects significantly.


The effects of 4-HO-DiPT are broadly comparable to those of other serotonergic psychedelics such as LSD and psilocybin, but they are distinguished by their relative brevity. Shulgin "doubt[s] that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitivity to dose, at least one that is active orally." An idiosyncratic effect of the drug, also noted by Shulgin, is its tendency to induce tremors.[2][3][4]

Some users have reported a minor audio distortion with lower dosages. Higher dosages increase the polarity of the distortion. It is defined as being slightly lower in pitch and creating several different effects, such as pitch bend, volume distortion, and rate distortion. As with most DiPT psychedelics, music can become more dissonant and less harmonious. Users have also reported a visual distortion widely comparable to the hallucinogen LSD.



Binding Sites Binding Affinity Ki (μM)[5]
5-HT1A 5.7
5-HT2A 0.728
5-HT2C 2.8
D1 >25
D2 >25
D3 >25
α1A >12
α2A 15
TAAR1 >15
H1 9.8
SERT 1.8
DAT >26
NET 11

Clinical trials

FT-104, a prodrug to 4-HO-DiPT, has entered double blind, randomized, placebo controlled, phase 1 clinical trials in healthy volunteers at the Royal Adelaide Hospital in Australia for the treatment of postpartum depression and treatment-resistant depression. [6][7][8]

FT-104 [1]
FT-104 [1]

Legal Status


Sveriges riksdags health ministry Statens folkhälsoinstitut classified 4-HO-DiPT as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of Mar 1, 2005, in their regulation SFS 2005:26 listed as 4-hydroxi-N,N-diisopropyltryptamin (4-HO-DIPT), making it illegal to sell or possess.[9]

United States

4-HO-DiPT is not scheduled at the federal level in the United States,[10] but it is possible that it could be considered an analog of 5-MeO-DiPT, in which case purchase, sale, or possession could be prosecuted under the Federal Analog Act.


"4-Hydroxy-N,N-diisopropyltryptamine" is a Schedule I controlled substance in the state of Florida making it illegal to buy, sell, or possess in Florida.[11]


  1. ^ Erowid.org 4-HO-DiPT Dosage Vault
  2. ^ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252.
  3. ^ "4-Hydroxy-DIPT". Erowid.
  4. ^ "Tihkal 4-HO-DIPT entry".
  5. ^ Rickli A, Moning OD, Hoener MC, Liechti ME (August 2016). "Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens" (PDF). European Neuropsychopharmacology. 26 (8): 1327–37. doi:10.1016/j.euroneuro.2016.05.001. PMID 27216487. S2CID 6685927.
  6. ^ "Field Trip Announces First Dosings in Phase I Clinical Study of FT-104". 21 July 2022.
  7. ^ "An Inside Look into Field Trip's Next-Generation Psychedelic, FT-104". 11 August 2022.
  8. ^ Bryson N. Tryptamine prodrugs. Patent US2021/0403425
  9. ^ "Svensk författningssamling" [Swedish Code of Statutes] (PDF) (in Swedish).
  10. ^ "21 CFR — SCHEDULES OF CONTROLLED SUBSTANCES §1308.11 Schedule I." Archived from the original on 2009-08-27. Retrieved 2014-12-17.
  11. ^ Florida Statutes - Chapter 893 - DRUG ABUSE PREVENTION AND CONTROL