RPS21
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX, 3J7R, 4D61, 4D5L, 4UJD, 3J7P, 4UJE, 4UJC
Identifiers
Aliases	RPS21, HLDF, S21, ribosomal protein S21
External IDs	OMIM: 180477 MGI: 1913731 HomoloGene: 90915 GeneCards: RPS21
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.33 Start 62,387,103 bp[1] End 62,388,520 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band n/a Start 180,257,377 bp[2] End 180,258,445 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple human penis spongy bone middle frontal gyrus superficial temporal artery caput epididymis thymus vulva oral cavity lactiferous duct Top expressed in hand endocardial cushion medial ganglionic eminence vas deferens atrioventricular valve condyle cervix supraoptic nucleus maxillary prominence fossa More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein N-terminus binding structural constituent of ribosome RNA binding Cellular component small ribosomal subunit intracellular anatomical structure cytosol cytosolic small ribosomal subunit ribosome nucleoplasm cytoplasm endoplasmic reticulum rough endoplasmic reticulum polysomal ribosome synapse Biological process endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) translational initiation SRP-dependent cotranslational protein targeting to membrane nuclear-transcribed mRNA catabolic process, nonsense-mediated decay viral transcription protein biosynthesis rRNA processing cytoplasmic translation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6227 66481 Ensembl ENSG00000171858 ENSMUSG00000039001 UniProt P63220 Q9CQR2 RefSeq (mRNA) NM_001024 NM_025587 RefSeq (protein) NP_001015 NP_079863 NP_001342445 NP_001342446 NP_001342447 NP_001342449 NP_001342450 Location (UCSC) Chr 20: 62.39 – 62.39 Mb Chr 2: 180.26 – 180.26 Mb PubMed search [3] [4]
Wikidata
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40S ribosomal protein S21 is a protein, encoded in humans by the RPS21 gene.^[5][6][7]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S21E family of ribosomal proteins.

It is located in the cytoplasm. Alternative splice variants that encode different protein isoforms have been described, but their existence has not been verified. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[7]

Interactions

RPS21 has been shown to interact with Ribosomal protein SA.^[8][9]