RPS27
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS27, MPS-1, MPS1, S27, ribosomal protein S27, DBA17
External IDs	OMIM: 603702 HomoloGene: 803 GeneCards: RPS27
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.3 Start 153,990,762 bp[1] End 153,992,155 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence canal of the cervix lymph node Achilles tendon uterine tube corpus callosum gastric mucosa right uterine tube left uterine tube left lobe of thyroid gland n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding structural constituent of ribosome zinc ion binding metal ion binding protein binding RNA binding Cellular component cytosol ribosome intracellular anatomical structure nucleus nucleoplasm cytosolic small ribosomal subunit postsynaptic density presynapse glutamatergic synapse GABA-ergic synapse Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation ribosomal small subunit assembly nuclear-transcribed mRNA catabolic process, nonsense-mediated decay cell population proliferation protein biosynthesis sister chromatid cohesion rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6232 n/a Ensembl ENSG00000177954 n/a UniProt P42677 n/a RefSeq (mRNA) NM_001030 NM_001349946 NM_001349947 n/a RefSeq (protein) NP_001021 NP_001336875 NP_001336876 n/a Location (UCSC) Chr 1: 153.99 – 153.99 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

40S ribosomal protein S27, also known as metallopan-stimulin 1 or MPS-1, is a protein that in humans is encoded by the RPS27 gene.^[3][4][5] Metallopanstimulin is a zinc finger protein proposed to be involved DNA repair as well as oncogenesis.^[6]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[5]

Clinical significance

Its expression is increased in several types of malignancy and MPS levels have been reported to drop with treatment of some cancers. It has also been used as a target for some chemotherapies, which aim to chelate out the zinc from the zinc finger motif of the MPS, thus yielding it inactive. These therapies have shown promise for the treatment of cancer in laboratory experiments and some limited clinical trials. Head and neck cancer transfected to overexpress this protein have demonstrated suppressed growth.^[6]