FAU
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2L7R,%%s4UG0, 4V6X, 5A2Q, 5AJ0, 5FLX
Identifiers
Aliases	FAU, FAU1, Fub1, Fubi, MNSFbeta, S30, asr1, Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed, ubiquitin like and ribosomal protein S30 fusion, FAU ubiquitin like and ribosomal protein S30 fusion, RPS30
External IDs	OMIM: 134690 MGI: 102547 HomoloGene: 37562 GeneCards: FAU
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.1 Start 65,120,630 bp[1] End 65,122,177 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 4.34 cM Start 6,107,874 bp[2] End 6,109,554 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix monocyte amygdala right uterine tube bone marrow cells putamen nucleus accumbens substantia nigra pituitary gland lymph node Top expressed in spleen thymus urinary bladder bone marrow duodenum jejunum yolk sac colon pancreas adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding structural constituent of ribosome Cellular component cellular component cytosol ribosome intracellular anatomical structure cytosolic small ribosomal subunit small ribosomal subunit nucleoplasm extracellular space Biological process biological process viral transcription SRP-dependent cotranslational protein targeting to membrane innate immune response in mucosa translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2197 14109 Ensembl ENSG00000149806 ENSMUSG00000038274 UniProt P35544 P62861 P35545 P62862 RefSeq (mRNA) NM_001997 NM_001160239 NM_001190436 NM_007990 RefSeq (protein) NP_001988 NP_001153711 NP_001177365 NP_032016 Location (UCSC) Chr 11: 65.12 – 65.12 Mb Chr 19: 6.11 – 6.11 Mb PubMed search [3] [4]
Wikidata
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40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.^[5][6]

Function

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein FUBI at the N-terminus and ribosomal protein S30 at the C-terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin.^[6]