5-(Trifluoromethyl)-DMT

Clinical data
Other names	5-TFM-DMT
Identifiers
IUPAC name N,N-dimethyl-5-(trifluoromethyl)-1H-Indole-3-ethanamine
CAS Number	2418713-31-0 Y
PubChem CID	154577546
Chemical and physical data
Formula	C13H15F3N2
Molar mass	256.272 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCC1=CNC2=CC=C(C(F)(F)F)C=C21
InChI InChI=InChI=1S/C13H15F3N2/c1-18(2)6-5-9-8-17-12-4-3-10(7-11(9)12)13(14,15)16/h3-4,7-8,17H,5-6H2,1-2H3 Key:VOLQGCCSWTZFGQ-UHFFFAOYSA-N

5-TFM-DMT (5-(trifluoromethyl)-DMT, 5-CF3-DMT, 5-(trifluoromethyl)-N,N-dimethyltryptamine) is a putative psychedelic tryptamine derivative related to drugs such as 5-MeO-DMT, 5-Fluoro-DMT, and 5-TFMO-DMT. It acts as a partial agonist at the 5-HT_2A receptor, with an EC₅₀ of 185.7 nM and an efficacy of 28.7% (vs 5-HT), and a full agonist at 5-HT_2C with an EC₅₀ of 89.7 nM and an efficacy of 88.8%, and no significant activity at 5-HT_2B.^[1]